Graduate Training at the Chemistry Biology Interface

描述(由申请人提供)：本提案是马里兰大学巴尔的摩分校(UMBC)化学-生物学接口研究生课程的续签申请。该项目于1998年在密歇根州立大学启动，在2004年7月首次获奖之前一直由该大学独资资助。该计划旨在为化学、生物化学和生物专业的学生提供跨学科培训的机会。到目前为止，已有13名博士生得到了培训补助金的资助，另外还有19名博士生从大学获得了更多的津贴。密歇根州立大学CBI项目的学生是四个博士学位项目的一部分：化学、生物学、分子和细胞生物学，以及由密歇根州立大学化学系和马里兰大学巴尔的摩分校(UMB)市中心校区的生物化学和分子生物学系联合开办的生物化学项目。跨学科培训是通过几种方式完成的，一是在相反学科的实验室轮换，在相反学科开设高级课程，以CHEM 715课程的形式每两周举行一次会议，“化学-生物界面的问题”，在那里学生参与关于职业问题的讨论，学习如何进行研究演讲，回顾和展示各种“热门”主题领域的文献，以及主持来访的研讨会演讲者。更重要的是，自最初的资助期以来，该计划增加了一个新功能，即由学生的研究导师与培训机会导师共同为每个学生专门设计的正式培训机会。新的培训机会旨在为学生提供更有意义的体验，同时加强他们的论文研究。目前学生的部分研究项目包括：“用于激活乳腺癌特异性CD4+T细胞的新型MHCⅡ限制性多肽”、“在大肠杆菌中Rob和Soxs的蛋白质-蛋白质相互作用及其在应激防御反应系统中的作用”、“新型G蛋白偶联受体黑素依赖的磷酸化失活的研究”、“结合在抑制P53结合的小分子上的S100B的特性”、“APE1在DNA糖基酶刺激中的重要性”、“TDG和APE1之间的关系的表征”、“氨基黄酮类抗癌药物的活性代谢物的化学表征”。CBI项目的独特之处在于，CBI学生从一年级到毕业，不管他们是否获得了培训补助金，因此确保了持续的指导、指导和接触跨学科的科学。

DESCRIPTION (provided by applicant): This proposal is a renewal application for the Chemistry-Biology Interface Graduate program at the University of Maryland, Baltimore CO (UMBC). This program was started at UMBC in 1998, and solely funded by the university until the initial award in July 2004. The program was initiated to provide opportunities for cross-disciplinary training for chemistry, biochemistry and biology students. To date thirteen Ph.D. students have been funded by the training grant in addition to another nineteen Ph.D. students that have received increased stipends from the university. Students in the UMBC CBI program are part of four Ph.D. degree programs; Chemistry, Biology, Molecular and Cellular Biology and the joint Biochemistry program run by the Chemistry department at UMBC and the Department of Biochemistry and Molecular Biology at the University of Maryland Baltimore (UMB) downtown campus. Cross-disciplinary training is accomplished in a number of ways, one, the possibility for a rotation in a laboratory in the opposite discipline, an upper level course in the opposite discipline, biweekly meetings in the form of a class CHEM 715, "Issues at the Chemistry-Biology Interface", where the students participate in discussions on career issues, learn how to give research talks, review and present literature from a wide variety of "hot" topic areas, as well as to host visiting seminar speakers. More significantly, a new feature of the program has been added since the initial funding period, a formal training opportunity with a mentor in the opposite discipline, specifically designed for each student by the student's research mentor in conjunction with the training opportunity mentor. The new training opportunity is designed to give the student a more meaningful experience in addition to enhancing their dissertation research. Some of the current students' research projects include: "Novel MHC ll-restricted peptides for activating breast cancer-specific CD4+ T cells", "Protein-Protein Interactions of Rob and SoxS and their Role in Stress Defense Response Systems in E. coli", "Investigation of phosphorylation dependent deactivation of the novel G protein coupled receptor melanopsin", "Characterizing S100B Bound to Small Molecules that Inhibit p53 Binding", "The Importance of APE1 in the Stimulation of DNA Glycosylases", "Characterization of the Relationship between TDG and APE1", and "Chemically characterizing the active metabolite of aminoflavone anticancer drugs". Unique to our program, the CBI students participate from year one until they graduate, regardless of whether or not they are on the training grant, thus insuring continual mentorship, guidance and exposure to cross-disciplinary science.