Cerebrovascular Research Training Program

描述（由申请人提供）：本提案旨在为西奈山医学院神经内科、神经外科、神经科学和急诊医学部门以及西奈山中风和医学中心生物科学研究生院提供一个新的高度集中的脑血管疾病博士后培训项目。非常强大的跨部门和多学科合作得到了培养和巩固，来自美国国立卫生研究院的校外资金也呈指数级增长。基于丰富和不断扩大的研究存在，以及一个成熟的、积极的和有竞争力的培训组成部分，我们寻求在这些部门的实力得到证实的领域中，将下一代医生和研究科学家的研究培训和职业发展正规化。我们已经采取了多个具体步骤来确保临床和基础教师导师之间的衔接。鉴于中风引起的巨大疾病负担以及随着人口老龄化中风的日益流行，我们的建议是及时的。此外，由于西奈山服务于一个三种族社区，少数民族患中风的比例不成比例，因此它准备吸引对推进少数民族中风保健问题感兴趣的少数民族申请人。在脑血管项目和神经保护项目的广度和深度范围内，博士后学员（医学博士和/或博士）将获得一个优秀的指导，个性化的环境（10名nih资助的导师），他们可以沉浸在基础/教学课程中，包括儿科脑血管疾病，实验设计和方法以及其他研究技术(如拨款写作，伦理行为)严格适用于主要的基础或临床调查研究领域。博士后受训者将受到密切的监督和指导，能够通过结构化的、互动的环境过渡到一个独立的、基础的或临床的神经科学家。重点是独立研究，展示思维技能，批判性推理，科学写作，演讲和合作。通过积极的招聘策略，包括对少数族裔申请人的关注，研究员将接受2-3年的培训。我们期待招聘具有研究经验但对脑血管疾病/神经保护/细胞死亡知识有限的博士，以及寻求强化、高水平转化研究培训的医学博士（临床训练的神经科医生、神经外科医生和急诊医生），使他们能够成功地成为未来的研究者。我们还将招收医学博士。准备把他们的综合技能集中在一个特定的常见的、致残的神经系统疾病上。该项目将由Levine博士（主任）管理，他是一位经验丰富、成功的导师和研究员，也是一个精心挑选的执行委员会。我们将提供培训和经验，以及一个定制的咨询委员会，使博士后在完成我们的项目后成为独立和成功的研究者。由于中风是美国第三大死亡原因，也是导致成人残疾的头号原因，因此中风仍然是当今美国主要的公共卫生问题之一。尽管如此，加上美国人口老龄化，政府指定的中风研究培训项目却很少。我们的建议将增加一个中风培训项目，重点是培养下一代中风研究人员，在一个优秀的研究和培训环境中，通过临床和基础研究的几种途径来解决中风问题。

DESCRIPTION (provided by applicant): This proposal is for a new highly focused postdoctoral training program in cerebrovascular disease that will be based in the Departments of Neurology, Neurosurgery, Neuroscience, and Emergency Medicine at The Mount Sinai Schools of Medicine and Graduate School of Biological Sciences within the Mount Sinai Stroke and Medical Centers. Very strong interdepartmental and multi-disciplinary collaborations have been fostered and solidified, and extramural funding from the NIH has grown exponentially. Based on a fertile and expanding research presence with an established, active and competitive training component, we seek to formalize the research training and career development of the next generation of physician and research scientists in this arena of proven strength within these departments. We have taken multiple concrete steps to insure a cohesive program among the clinical and basic faculty mentors. Our proposal is timely given the tremendous burden of illness stroke causes and the growling epidemic of stroke as the population ages. Further, as Mount Sinai serves a tri-racial community, with minorities experiencing a disproportionate share of stroke, it is poised to attract minority applicants interested in advancing minority health-care issues in stroke. Within the breadth and depth of the cerebrovascular program and the neuroprotection programs, postdoctoral trainees (M.D.s and/or Ph.D.s) will be given an outstanding mentored, individually crafted milieu (10 NIH-funded mentors) where they can immerse in basic/didactic course work, including pediatric cerebrovascular disease, experimental design and methodology and other research techniques (e.g. grant writing, ethical conduct) critically applied to either primarily basic or clinical investigative areas of research. Postdoctoral trainees will be closely supervised and mentored to be able to transition to an independent, basic or clinical neuroscientist through a structured, interactive environment. The focus is on independent research, demonstrating skills of thought, critical reasoning, scientific writing, and presentations, and collaboration. With active recruiting strategies, including attention to minority applicants, fellows will train for a period of 2-3 years. We anticipate recruiting Ph.D.s with research experience but with limited knowledge of cerebrovascular diseases/neuroprotection/cell death, and M.D.s (clinically trained neurologists, neurosurgeons, and emergency medicine physicians) seeking intensive, high-level translational-oriented research training allowing them to compete successfully as future investigators. We will also recruit M.D.-Ph.D.s ready to focus their combined skills towards a specific common, and disabling neurological disease. The program will be administered by Dr. Levine (Director), an experienced and successful mentor and researcher and a carefully chosen Executive Committee. We will provide the training and experience and a customized Advisory Committee that will allow postdoctoral fellows to become independent and successful investigators upon completion of our program. As stroke is the third leading cause of death in America and the number one cause of adult disability, stroke remains one of the major public health problems in the United States today. Despite this, and the aging population of America, there are very few government-designated training programs in stroke research in the country. Our proposal would add a stroke training program that will focus on preparing the next generation of stroke researchers to tackle the problem of stroke via several avenues of clinical and basic research within an outstanding research and training environment.