General Clinical Research Center

港湾-加州大学洛杉矶分校医疗中心的GCRC和锡达斯-西奈医疗中心的卫星GCRC正在申请继续为GCRC提供5年的资金(2006年12月1日至2011年11月30日)。港湾-加州大学洛杉矶分校GCRC请求支持住院病房(800天)、门诊设施(9,000次就诊)、围产期/儿科病房(7,000小时)。Cedars GCRC卫星正在为一个门诊部、一个复杂的基因表型核心和一个与港湾同行密切合作的围产期单位寻求持续支持。目前的应用程序包含来自Harbor的93个协议和来自Cedars的95个协议，每个协议都有数据安全监控计划。GCRC正在请求支持一个新的临床转录基因组学、蛋白质组学和分子细胞学联合核心，其中有47项协议利用了这一提议的核心。由于NCRR的预算限制，这一核心在2004年没有得到资助，并获得了极高的分数。与GCRC的母公司赠款类似，CORE的优势包括调查人员的杰出资质--CORE主任，提供培训环境的能力，以及来自广泛学科的大量调查人员和方案。在过去两年中，我们的机构慷慨地提供了主要设备，并为运行拟议核心的人员提供了临时支助。我们提出的方案展示了我们资金雄厚的研究人员的广泛基础，这些研究包括新出现的感染、慢性肾脏疾病、自身免疫中的成纤维细胞、男性生殖、神经创伤、骨骼发育不良和炎症性肠病。我们支持高容量的门诊研究(SELECT、营养学和肾脏疾病)、高强度住院研究(I期安全性和药代动力学研究、代谢和多样本研究)、围产期研究(生殖毒理学、暴露于甲基苯丙胺的婴儿)、行为研究(抑郁症、酒精依赖)和常见疾病的遗传学(糖尿病、糖尿病肾病、骨质疏松症、动脉粥样硬化)。GCRC是各自机构临床研究培训的重点，面向初级教员、研究员、少数族裔研究生和本科生，我们的培训活动在上次审查中被评为“杰出”。GCRC的定位是成为我们机构临床和翻译科学中心的一部分，遵循NIH路线图，重新设计全国学术卫生中心的临床研究企业。

The GCRC at Harbor-UCLA Medical Center and the satellite GCRC at Cedars-Sinai Medical Center are applying for continued funding of the GCRCs for 5 years (12/01/2006 to 11/30/2011). The Harbor-UCLA GCRC is requesting support for an inpatient unit (800 days), outpatient facilities (9,000 visits), a perinatal/ pediatrics unit (7,000 hrs). The Cedars GCRC satellite is seeking continued support for an outpatient unit, a complex genotype-phenotype core and a perinatal unit working closely with its Harbor counterpart. The current application contains 93 protocols from Harbor and 95 from Cedars, each with Data Safety Monitoring plans. The GCRCs are requesting support for a new joint Clinical Transcriptional Genomics, Proteomics and Molecular Cytology core with 47 protocols utilizing this proposed core. Reviewed and given an excellent score, this core was not funded in 2004 because of NCRR's budgetary constraints. Similar to the GCRC parent grant, the core's strengths include outstanding qualifications of the investigators-core directors, the capability to provide a training environment, and a substantial number of investigators and protocols from a broad range of disciplines. Our institutions have generously provided major equipment in the past 2 years and provided interim support for personnel to run the proposed core. Our presented proto-cols demonstrate the broad base of our well-funded investigators with diverse research including emerging infections, chronic kidney disease, fibroblasts in autoimmunity, male reproduction, neurotrauma, skeletal dysplasia and inflammatory bowel disease. We support high-volume outpatient studies (SELECT, Nutrition and Kidney Disease), high-intensity inpatient studies (Phase I safety and pharmacokinetics studies, metabolic and multiple sample studies), perinatal research (reproductive toxicology, methamphetamine exposed babies), behavior studies (depression, alcohol dependence), and genetics of common diseases (diabetes, diabetic nephropathy, osteoporosis, atherosclerosis). The GCRCs are the focus of clinical research training in their respective institutions reaching out to junior faculty, fellows, and minority graduate and undergraduate students, and our training activity is ranked "outstanding" in our last review. The GCRCs are positioned to be part of Centers for Clinical and Translational Sciences in our institutions following the NIH Roadmap to reengineer the clinical research enterprise of academic health centers in the nation.