National Alzheimer's Coordinating Center (NACC)

描述（由申请人提供）：本申请是为国家阿尔茨海默病协调中心（NACC）[U 01 AG 016976]的竞争性延续而提出的，该中心于1999年首次获得资助，以响应国家老龄化研究所（NIA）发布的RFA，随后于2004年更新。本申请的申请期限为2009年7月1日至2014年6月30日。与最初的RFA以及NIA和阿尔茨海默病中心（ADC）计划在前几个资助周期中的累积和发展意图一致，NACC的使命是开发和维护一个通用/标准化数据库，说明所有ADC的入组情况，并直接基于数据库以及通过ADC研究者的独立倡议促进ADC之间的合作研究。为此目的，NACC为调查员发起的合作项目和直接基于数据库的初级调查员二级数据分析项目提供竞争性、同行审查的资金。NACC与ADC密切合作，提供数据管理，统计和研究咨询，并进行自己的方法和实证科学调查。具体而言：维护和进一步开发NACC数据库，并促进其用于研究;继续并建立统一数据集（UDS）数据质量保证和质量控制程序;通过研究资金和技术支持促进ADC之间的合作研究;开发与AD和相关疾病研究相关的新方法工具和方法;对NACC数据库中的具体内容领域进行描述性和分析性研究;履行NACC的NIA所需的行政职能：为主任和核心领导人会议提供后勤支持，与NIA倡议小组进行交流;分配资金以支持NACC的数据收集工作和合作项目;并促进ADC间的通信。

DESCRIPTION (provided by applicant): This application is for the competing continuation of the National Alzheimer Coordinating Center (NACC) [U01 AG016976] first funded in 1999 in response to an RFA issued by the National Institute on Aging (NIA) and subsequently renewed in 2004. The present application is for the period of July 1, 2009 through June 30, 2014. Consistent with the original RFA and the accrued, developed intent of the NIA and the Alzheimer Disease Centers (ADC) program during the previous funding cycles, the mission of the NACC is to develop and maintain a common/standardized database, accounting for the enrollment at all ADCs, and to facilitate collaborative research among the ADC's, based directly on the database as well as through independent initiatives of ADC investigators. To that end, NACC provides for competitive, peer reviewed funding of investigator initiated collaborative projects and for junior-investigator secondary data analysis projects based directly on the database. NACC works closely with ADCs providing data management, statistical and research consulting and conducts its own methodological and empirical scientific investigations In addition to these aspects NACC also has a variety of administrative responsibilities for interactions and communications across ADCs and with NIA. Specifically: To maintain and further develop the NACC database and facilitate its use for research; To continue and build upon the Uniform Data Set (UDS) data quality assurance and quality control procedures already in place; To promote collaborative research among the ADCs through research funding and technical support; To develop new methodological tools and approaches relevant to research on AD and related disorders; To conduct descriptive and analytic studies of specific content areas from the NACC database; To perform NACC's NIA-required administrative functions: provide logistical support for directors' and core leaders' meetings, interface with NIA initiative groups; distribute funds in support of NACC data collection effort and collaborative projects; and facilitate inter-ADC communication.