MicroRNAs and Human Disease - Olson, Chair

描述（由申请人提供）：本提案请求支持由Eric N.奥尔森，萨法里Kauppinen和伊娃货车Rooij，这将是在班夫，阿尔伯塔，加拿大于2011年2月11日至16日举行。MicroRNA已经成为许多疾病的关键调节因子，包括癌症、心脏病、神经系统疾病和血管异常。MicroRNA和人类疾病的Keystone研讨会将重点关注围绕miRNA在人类疾病中的功能和治疗机会的新发现。这次会议将汇集一系列疾病的科学和临床专家。由于该会议将与Keystone Symposia会议同时举行，该会议将重点关注癌症以外的疾病，如心血管，肌肉，传染病和神经系统疾病。联合全体会议将重点关注microRNA的作用机制和microRNA靶点的识别，以及microRNA在干细胞中作用的最新进展。会议将以关于microRNA疗法最新进展的联合会议结束。 公共卫生相关性：在过去的几年里，越来越清楚的是，microRNAs（miRNAs）-每个RNA的小片段调节数百个基因-在各种疾病状态中发挥重要作用，如癌症，中枢神经系统疾病，病毒，肌肉和心血管疾病。由于miRNA在多种疾病状态中的明显作用，人们对miRNA功能以及使用这些疾病调节剂作为治疗靶点和诊断工具的可行性的兴趣极大增加。基于该领域的快速发展，这次关于MicroRNA和人类疾病的Keystone研讨会将提供有关最新发现的见解和清晰度，并促进在该领域工作的科学领导者，学生和学员之间的互动。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Microns and Human Disease, organized by Eric N. Olson, Safari Kauppinen and Eva van Rooij, which will be held in Banff, Alberta, Canada from February 11 - 16, 2011. MicroRNAs have emerged as key regulators of numerous diseases including cancer, heart disease, neurological disorders and vascular abnormalities. The Keystone Symposia meeting on MicroRNAs and Human Disease will focus on new discoveries surrounding the function and therapeutic opportunities of miRNAs in human disease. This meeting will bring together a broad range of scientific and clinical experts in a number of diseases. Because the meeting will be held concurrently with the Keystone Symposia meeting on MicroRNAs and Non-Coding RNAs and Cancer, this meeting will focus on diseases other than cancer, such as cardiovascular, muscle, infectious, and neurological diseases. Joint plenary sessions will focus on microRNA mechanisms of action and the identification of microRNA targets, as well as the latest advances on the roles of microRNAs in stem cells. The meetings will conclude with a combined session on recent advances in microRNA therapeutics. PUBLIC HEALTH RELEVANCE: In the last few years it has become increasingly clear that microRNAs (miRNAs) - small segments of RNA that each regulate hundreds of genes - fulfill important roles in a variety of disease states like cancer, central nervous system disorders, viral, muscle and cardiovascular disease. Due to the apparent roles of miRNAs in multiple disease states, there has been a tremendous increase in interest in miRNA function and the feasibility of using these disease regulators as therapeutic targets and diagnostic tools. Based on rapid developments in this field, this Keystone Symposia meeting on MicroRNAs and Human Disease will provide insight and clarity regarding recent discoveries as well as facilitate interactions among scientific leaders, students and trainees working in this field.