POST-EXPOSURE MONITORING OF LENTIVIRUS-INFECTED MACAQUES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 该项目旨在作为一个控股和资源项目 不再需要的已感染SIV或HIV的动物 在最初的项目上。这些动物将被饲养在BSL-2/3 设施，要么是在I翼，要么是在PFS。他们将受到监控 在临床上有助于确定该病的自然发病机制。不是 将对这一项目进行研究；然而，动物可能会 重新分配到其他项目，作为实验药物的研究对象 评估、发病机制研究、疫苗研究或需要 免疫抑制和/或SIV/HIV病毒携带者。 每2-3个月采一次血进行病毒分离、血清学、CBC、 血清化学和T细胞亚群分析。如果一只动物 应该对治疗没有反应，或者应该死亡，完全尸检 将使用标准的SIV/HIV病理方案进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project is designed to act as a holding and resource project for animals that have been infected with SIVor HIV that are no longer required on the original project. The animals will be maintained in BSL-2/3 facilities, either in the I- Wing or at the PFS. They will be monitored clinically to help define the natural pathogenesis of the disease. No research will be done on this project; however, the animals may be reassigned to other projects to serve as subjects in experimental drug evaluations, pathogenesis studies, vaccine studies, or studies requiring immunosuppressed and/or SIV/HIV-viremic animals. Blood will be drawn every 2-3 months for viral isolation, serology, CBC, serum chemistry, and T- cell subset analysis. In the event that an animal should become unresponsive to treatment or should die, a complete necropsy will be performed using the standard SIV/HIV pathology protocol.