MONTE CARLO METHODS FOR FIBER OPTIC PROBE DESIGN

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该项目的主要目标是使用蒙特卡罗模拟开发新型光纤内窥镜，该内窥镜可以使用倾斜收集光纤几何形状同时探测上皮和基质形态。我们将使用以前报道的散射特性的人类上皮细胞预测和表征收集效率和深度分辨率不同的探针设计。设计参数将包括源检测器分离;照明和收集光纤之间的各种角度;光纤直径;收集光纤的数量等。我们将改变上皮的光学特性，以反映早期癌症的发展，并将优化探针设计，以实现最高的灵敏度，光学变化与癌变的发生。理论预测将使用定义良好的人类上皮多层光学模型进行测试。该项目的成功完成可以导致开发一种简单的仪器，用于通过反射光谱法进行非侵入性的、真实的时间的体内癌前检测和监测。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The main goal of this project is to use Monte Carlo simulations in development of novel fiber optic endoscopes that can simultaneously probe the epithelial and stromal morphology using oblique collection fiber geometry. We will use previously reported scattering properties of human epithelium to predict and to characterize collection efficiency and depth resolution of different probe designs. Design parameters will include source-detector separation; various angles between illumination and collection fibers; fiber diameter; number of collection fibers, etc. We will change optical properties of the epithelium to reflect early cancer development and will optimize probe design to achieve the highest sensitivity to optical changes that are associated with an onset of carcinogenesis. Theoretical predictions will be tested using well defined multi-layered optical phantoms of human epithelium. Successful completion of the project can lead to development of a simple instrument for non-invasive, real time in vivo pre-cancer detection and monitoring via reflectance spectroscopy.