NATIONAL NEUROLOGICAL AIDS BANK

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项申请代表着国家神经艾滋病银行(NNAB)的续签，NNAB是国家神经艾滋病组织联盟(NNTC)的成员。NNAB是一项纵向研究，对象是具有良好特征的晚期艾滋病患者和HIV血清阴性(HIV-)患者，他们同意在有生之年接受一系列神经和神经心理检查，并在有生之年捐献血液、尿液和脑脊液(CSF)，并在死后捐献器官和组织。NNAB收集这些组织和器官，并将它们分发给合格的研究人员，用于研究神经艾滋病的发病机制。NNAB使用神经内科、神经心理学、精神病学/物质滥用和神经病理学的标准化NNTC方案来描述其队列，以实现由NNTC质量保证委员会监督的共识诊断。此外，NNAB独立地收集必要的信息，以研究丙型肝炎病毒(丙型肝炎病毒)感染、高血压、糖尿病、血脂紊乱等并存疾病之间的联系，以及逆转录病毒治疗和艾滋病毒神经疾病的不良影响。NNAB的队列是独一无二的，因为它的多样性，并反映了性别，民族和种族分布在洛杉矶艾滋病。NNAB是85%的男性和15%的女性；我们的队列中超过60%的人是少数族裔成员，20%的人只会说西班牙语，8%的人受教育时间不到6年。在这次更新中，我们计划扩大我们的队列，利用我们在加州大学洛杉矶分校医疗中心、Olive View-UCLA医疗中心、查尔斯·R·德鲁大学和南加州大学医院之间的合作。NNAB刺激了独立资助的项目的发展，研究脑脊液病毒载量、丙型肝炎病毒和神经系统，以及作为跟踪艾滋病毒神经疾病的工具的磁共振波谱(MRS)。这些项目及其产生的信息进一步丰富了我们组织收集的价值。NNAB提供了一种日益重要的资源，反映了艾滋病流行不断变化的面貌，并能够根据调查人员的需要进行调整。NNAB为NNTC、科学界和艾滋病患者提供了宝贵的资源。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This application represents the renewal of National Neurological AIDS Bank (NNAB), a member of the National Neuro-AIDS Tissue Consortium (NNTC). NNAB is a longitudinal study of well-characterized subjects with advanced AIDS and HIV-seronegative (HIV-) subjects, who have agreed to have serial neurological and neuropsychological examinations during their life, and to donate blood, urine and cerebrospinal fluid (CSF) during life and their organs and tissues after their death. NNAB collects these tissues and organs and distributes them to qualified investigators for research into the pathogenesis of Neuro-AIDS. NNAB characterizes its cohort using standardized NNTC protocols in Neuromedicine, Neuropsychology, Psychiatry/Substance Abuse, and Neuropathology, to achieve consensus diagnoses that are monitored by the NNTC Quality Assurance Committees. In addition, NNAB independently collects information that is essential to study the association between co-morbid medical conditions, such as Hepatitis C virus (HCV) infection, hypertension, diabetes, lipid disorders, as well as the adverse effects of retroviral therapy and HIV neurological disease. The NNAB cohort is unique because of its diversity, and reflects the gender, ethnic, and racial distribution of AIDS in Los Angeles. NNAB is 85% male and 15% female; over 60% of our cohort is a member of racial and ethnic minorities, 20% are monolingual in Spanish, and 8% have less than 6 years of education. In this renewal, we plan to expand our cohort, utilizing our collaborations among UCLA Medical Center, Olive View-UCLA Medical Center, Charles R. Drew University, and USC University Hospital. NNAB has stimulated the development of independently funded projects studying CSF viral load, HCV and the nervous system, and magnetic resonance spectroscopy (MRS) as a tool for following HIV neurological disease. These projects and the information they generate further enrich the value of our tissue collection. NNAB provides an increasingly important resource that mirrors the changing face of the AIDS epidemic and is capable of adapting as the needs of investigators dictate. NNAB provides an invaluable resource to the NNTC, the scientific community, and people living with AIDS.