REGULATION OF MUCIN-RELATED GENE EXPRESSION

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们正在分析肠道细菌(空肠弯曲菌)感染的小鼠模型中编码肠道粘蛋白生物合成酶和核心蛋白的转录本。澳大利亚南布里斯班的Mater医学研究所的Michael McGuckin博士正在制作受感染的小鼠肠道样本，Karlsson博士正在分析粘蛋白结构，而我们的团队正在分析转录水平。这些研究的目标是检测在肠道细菌感染挑战后粘蛋白表达的反应。这些研究才刚刚开始，我们预计正在进行的合作可能需要一段时间才能以提交的手稿的形式取得成果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are analyzing transcripts encoding intestinal mucin biosynthetic enzymes and core proteins in a mouse model for intestinal bacterial (Campylobacter jejuni) infection. Samples of infected mouse intestine are being generated by Dr. Michael McGuckin (Mater Medical Research Institute, South Brisbane, Australia) and Dr. Karlsson is analyzing mucin structures, while our group is analyzing transcript levels. The goals of these studies are to examine the responses in mucin expression following a challenge of bacterial infection in the intestinal tract. These studies have just started and we anticipate an ongoing collaboration that may take a period of time to reach fruition in the form of submitted manuscripts.