Growing to Extremes: Cell Biology and Pathology of Axons

描述(申请人提供)：请求支持由Valeria Cavalli、Michael Fainzilber和Jeffery L.Twiss组织的题为生长到极端：轴突的细胞生物学和病理学的Keystone研讨会。会议将于2013年3月10日至15日在加利福尼亚州塔霍市举行。神经元的交流对于活动动物的每一次运动、感觉和思维都是必不可少的，神经元的轴突延伸提供了所有进出大脑和脊髓以及大脑和脊髓内的远程交流。在人类中，轴突的长度从数百微米到一米多不等，这两个长度都需要专门的形成和维护机制，并增加受伤或疾病时退化和功能障碍的风险。因此，基础研究人员和临床医生的不同群体必须解决根植于轴突细胞生物学的问题，但到目前为止，还没有会议作为这一领域的中心场所。过去的轴突生物学会议都集中在特定的子主题上，如轴突引导、营养因子或神经退行性变。这次会议将汇聚加速轴突生物学和病理学领域进展所需的多个学科，提供一个独特的场所，将轴突分子和细胞生物学的基础研究与临床需求和行业兴趣汇聚在一起。这次会议将涵盖分子和细胞轴突研究的最新进展，从中枢和外周神经系统的发育和维持，到生存和修复。其他主题和最新进展将通过从摘要中挑选出来的演讲纳入，特别是鼓励初级研究人员和该领域的新手参与。多学科主题和共同关注将促进从基础神经科学到临床神经科学的整个连续体的交流。 与公共健康相关：神经元通讯对活动动物的每一次运动、感觉和思考都是必不可少的，神经元的轴突延伸提供了所有进出大脑和脊髓以及大脑和脊髓内的远程通讯。2013年Keystone研讨会关于生长到极端：轴突的细胞生物学和病理学将提供一个独特的场所，将致力于轴突、轴突维护和轴突运输的分子和细胞生物学前沿的科学家聚集在一起。这次独特会议的目的是汇聚加快 在轴突生物学和病理学领域，并将这一认识应用于开发根植于轴突生物学的疾病和疾病的治疗方法。

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Growing to Extremes: Cell Biology and Pathology of Axons, organized by Valeria Cavalli, Michael Fainzilber and Jeffery L. Twiss. The meeting will be held in Tahoe City, California from March 10 - 15, 2013. Neuronal communication is essential for every movement, sensation and thought in motile animals, and the axonal extensions of neurons provide all long- range communication to, from, and within the brain and spinal cord. Axons extend distances ranging from hundreds of microns to more than a meter in humans, lengths that both require specialized mechanisms for formation and maintenance, and increase the risk of degeneration and dysfunction upon injury or disease. Thus, diverse communities of basic researchers and clinicians must address problems rooted in axonal cell biology, but to date there is no meeting that serves as a central venue for this field. Axon biology meetings in the past have focused on specific sub-topics such as axon guidance, trophic factors, or neurodegeneration. This meeting will bring together the multiple disciplines required for accelerating progress in the field of axoal biology and pathology, providing a unique venue to bring together basic research on molecular and cellular biology of axons with clinical needs and industry interest. The conference will cover a broad spectrum of the latest developments in molecular and cellular axonal research, from development and maintenance, through to survival and repair, in both the central and peripheral nervous systems. Additional topics and late-breaking developments will be incorporated via talks selected from abstracts, specifically encouraging participation of junior researchers and those new to the field. The multidisciplinary theme and shared focus will facilitate communication across the entire continuum from basic to clinical neuroscience. PUBLIC HEALTH RELEVANCE: Neuronal communication is essential for every movement, sensation and thought in motile animals, and the axonal extensions of neurons provide all long-range communication to, from, and within the brain and spinal cord. The 2013 Keystone Symposia meeting on Growing to Extremes: Cell Biology and Pathology of Axons will provide a unique venue to bring together scientists working at the cutting edge of molecular and cellular biology of axons, axonal maintenance, and axonal transport. The purpose of this unique meeting is to bring together the multiple disciplines required for accelerating the progress in the field of axonal biology and pathology and to apply this understanding to the development of treatments for diseases and conditions rooted in axon biology.