Concurrent Keystone Symposia meetings on Parkinsons and Alzheimers Diseases

描述（由申请人提供）：要求支持一对并行的基石研讨会会议，题为帕金森病：遗传学，机制和治疗（由帕特里克A。刘易斯，托马斯加塞和马塞尔P.货车德布鲁格）和阿尔茨海默氏症-从基本的见解到光在翻译隧道的尽头（由约翰Q。作者：Charles F. Albright和Hui Zheng）。这些会议将于2014年3月2日至7日在科罗拉多的Keystone举行。由于长寿革命，阿尔茨海默病（AD）、帕金森病（PD）和相关的神经退行性疾病在美国和全球变得越来越普遍。这些疾病的后果是严重的，无论是对个人和全球社会，促使人们担心，不断上升的医疗费用有可能导致有害影响 如果不尽快发现疾病缓解疗法，这将给国家经济带来灾难。关于帕金森病的Keystone研讨会会议将涵盖我们目前对PD全球遗传结构的了解，以及这如何为细胞遗传学提供信息。 和分子方法的疾病的病因，以及这些发现在患者诊断和开发新的治疗PD的影响。关于阿尔茨海默病的平行会议将探讨对AD机制的基本见解以及将这些知识转化为有意义的AD干预措施的机会。这些会议将分享一个主旨演讲和四个全体会议，结合起来，将探讨这两种破坏性疾病之间的共性，并讨论如何在每个领域的最新进展可以用来加速研究。此外，这些会议将与2014年也将在科罗拉多基斯通举行的落基山脉帕金森病协会年会重叠。Keystone研讨会将邀请协会与会者参加午餐会和其他非正式活动，我们预计Keystone研讨会与会者与协会与会者之间的互动将促进临床医生，患者和基础研究人员之间的新互动。

DESCRIPTION (provided by applicant): Support is requested for a pair of concurrent Keystone Symposia meetings entitled Parkinson's Disease: Genetics, Mechanisms and Therapeutics (organized by Patrick A. Lewis, Thomas Gasser and Marcel P. van der Brug) and Alzheimer's Disease - From Fundamental Insights to Light at the End of the Translational Tunnel (organized by John Q. Trojanowski, Charles F. Albright and Hui Zheng). These meetings will be held in Keystone, Colorado from March 2 - 7, 2014. Alzheimer's disease (AD), Parkinson's disease (PD) and related neurodegenerative disorders are becoming increasingly more prevalent in the United States and globally due to the longevity revolution. The consequences of these diseases are grave, both for individuals and the global community, prompting concerns that rising healthcare costs have the potential to result in deleterious effects on national economies that could spell disaster unless disease modifying therapies are discovered very soon. The Keystone Symposia meeting on Parkinson's disease will cover our current state of knowledge of the global genetic architecture of PD, how this is informing cellular and molecular approaches to the etiology of the disease, and the implications of these discoveries in patient diagnosis and development of novel treatments for PD. The parallel meeting on Alzheimer's disease will explore fundamental insights into mechanisms of AD and the opportunities they provide to translate this knowledge into meaningful interventions for AD. These meetings will share a keynote address and four plenary sessions which, in combination, will explore the commonalities between these two devastating disorders and discuss how recent advances in each field can be used to accelerate research. In addition, these meetings will overlap with the annual meeting of the Parkinson's Association of the Rockies that will also be held in Keystone, Colorado in 2014. Keystone Symposia will invite Association attendees to participate in luncheons and other informal activities and we anticipate that interactions between Keystone Symposia participants and the Association attendees will foster new interactions between clinicians, patients and basic researchers.