Comprehensive Cancer Center of Wake Forest COOP Research Base

描述(由申请人提供)：这是维克森林综合癌症社区临床肿瘤学计划研究基地(WF研究基地)的第三次竞争性续签申请，该基地最初于1999年获得资助。未来五年的具体目标包括以下方面：具体目标1：开展影响社区肿瘤学实践的癌症控制研究，通过预防和治疗以下专题领域的症状提高患者的生活质量(即从诊断到治疗结束，从治疗结束到治疗结束)：植物/天然产品和其他综合方法；常规药理制剂；行为干预；非干预研究(如相关科学和观察性/纵向研究；癌症预防试验)。具体目标2：将相关科学与WF研究基地的癌症控制研究相结合，以了解癌症及其治疗的症状和毒性发生的基本机制。具体目标3：制定和利用创新的、因地制宜的战略，以增加传统上在癌症控制研究中代表性不足的种族/族裔少数群体的参与。具体目标4：促进积极合作，并为CCOP/MBCCOP专业人员、早期职业教师和受训人员提供癌症控制临床试验的开发、实施和报告方面的培训。目前的申请是我们12年历史上最具竞争力的WF研究基地续签申请。随着时间的推移，我们增加了学习、应计项目和附属社区和机构的数量。我们的四个开放研究和四个即将开放的研究以及20个发展中概念的多样性、深度和广度证明了我们提供的独特和多样化的研究菜单，以及我们为参与的CCOP、MBCCOP和预防成员填补的重要利基市场。

DESCRIPTION (provided by applicant): This is the third competing renewal application for the Comprehensive Cancer of Wake Forest Community Clinical Oncology Program Research Base (WF Research Base), which was initially funded in 1999. Specific Aims for the next five years include the following: Specific Aim 1: To conduct cancer control studies that impact community oncology practice by enhancing patients' quality of life through prevention and treatment of symptoms across the survivorship lifespan (i.e., from diagnosis to the end of therapy and from the end of therapy forward) in the following thematic areas: botanical/natural products and other integrative approaches; conventional pharmacologic agents; behavioral interventions; non-intervention studies (e.g., correlative science and observational/longitudinal studies; and cancer prevention trials). Specific Aim 2: To use correlative science in conjunction with WF Research Base cancer control studies to understand the basic mechanisms by which symptoms and toxicities of cancer and its treatments occur. Specific Aim 3: To develop and utilize innovative, culturally-tailored strategies to increase the participation of racial/ethnic minorities traditionaly underrepresented in cancer control studies. Specific Aim 4: To foster active collaboration and offer training in the development, conduct, and reporting of cancer control clinical trials for CCOP/MBCCOP professionals, early career faculty, and trainees. The current application is the strongest competing renewal application for the WF Research Base in our 12 year history. Over time, we have increased the number of studies, accruals, and affiliated communities and institutions. The diversity, depth and breadth of our four open and four soon-to-open studies and 20 developing concepts is evidence of the unique and diverse menu of studies we provide, and the important niche we fill for our participating CCOPs, MBCCOPs and Prevention Members.