纯种 SPF 恒河猴的生产-猫眼课题宝

纯种 SPF 恒河猴的生产

批准号：

8650933

负责人：

Jeffrey A Roberts

金额：

$114.93万

依托单位：

UNIVERSITY OF CALIFORNIA AT DAVIS

依托单位国家：

美国

项目类别：

财政年份：

2000

资助国家：

美国

项目状态：

已结题

起止时间：

2000-09-30 至 2016-03-31

来源：

https://reporter.nih.gov/project-details/8650933

关键词：

Acquired Immunodeficiency Syndrome Address Age Alleles Animals Applications Grants Bioinformatics Biological Biomedical Research Birth Breeding California Cercopithecine Herpesvirus 1 Chinese People Cytomegalovirus DNA Fingerprinting Data Data Storage and Retrieval Derivation procedure Disease susceptibility Equilibrium Experimental Designs Foundations Funding Future Genetic Genotype Goals Grant Haplotypes Harvest Health Homeostasis Immunity Infant Infection Lymphoid Macaca mulatta Maintenance Major Histocompatibility Complex Microsatellite Repeats Mission Mothers Nurseries Organism Pathogenesis Positioning Attribute Predisposition Primates Principal Investigator Production Records Research Research Design Research Personnel Resources Rhadinovirus Role SIV Sampling Simian Foamy Virus Solid Specific Pathogen Frees Specimen Structure Taxon Type D Retrovirus Vaccines Viral Viral Pathogenesis Virus Work animal breeding biobank cohort data management data mining data sharing digital genetic pedigree genetic profiling germ free condition microbiome pathogen prevent programs public health relevance success vaccine development virology virus pathogenesis

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中文摘要

翻译

描述（由申请人提供）：本申请的目标是继续扩大对七种持久性病毒无特异性病原体（SPF）的印度血统遗传特征恒河猴的生产，包括猿猴免疫缺陷病毒（SIV）、猿猴D型逆转录病毒（SRV）、猿猴t淋巴细胞嗜性病毒（STLV）、猿猴疱疹病毒1 （B病毒）、猿猴泡沫病毒（SFV）、恒河猴巨细胞病毒（RhCMV）和恒河猴rhadinvirus （RRV）。这一拟议的扩展将面向生产用于艾滋病相关研究的SPF动物，并建立一个长期自我维持的SPF繁殖群体，该群体是具有已知血统和明确的MHC基因型的印度恒河猴。这个群体现在超过350只动物，并通过自然分娩和SPF母亲抚养自我维持。不再需要通过对传统育种者所生的婴儿进行育儿来衍生SPF育种者。

英文摘要

DESCRIPTION (provided by applicant): The goal of this proposal is to continue to expand the production of genetically characterized rhesus macaques of Indian-ancestry that are specific pathogen-free (SPF) for seven persistent viruses, including simian immunodeficiency virus (SIV), simian type D retrovirus (SRV), simian T-lymphotropic virus (STLV), Cercopithecine herpesvirus 1 (B virus), simian foamy virus (SFV), rhesus cytomegalovirus (RhCMV) and rhesus rhadinovirus (RRV). This proposed expansion will be geared to the production of SPF animals for use in AIDS-related research, and to establishing a long-term self-sustaining SPF breeding colony of Indian- origin rhesus macaques with known pedigree and well-defined MHC genotypes. This colony now exceeds 350 animals and is self-sustaining through natural birth and rearing by SPF mothers. Derivation of SPF breeders through nursery-rearing of infants born to conventional breeders is no longer required.

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