Positive Strand RNA Viruses

描述(由申请人提供)：请求支持由Eric J.Snijder和Ralf Bartenschlager组织的题为正链RNA病毒的Keystone研讨会。会议将于2013年4月28日至5月3日在马萨诸塞州波士顿举行。这次会议的总议题与NIAID的任务有关，涉及病毒病原体研究的广泛领域。最初发起于1986年的Keystone研讨会，后来由Margo Brinton博士作为主要组织者持续了25年以上，三年一度的正链RNA病毒国际研讨会为最近对具有正链RNA基因组的人类、动物、植物、昆虫和细菌病毒的研究提供了一个国际论坛。这些病原体构成了最大的病毒组，包括大量重要的人类病原体，如丙型肝炎病毒、西尼罗河病毒和登革热病毒、甲型肝炎病毒和脊髓灰质炎病毒。此外，在动物身上发现的种类繁多的正链RNA病毒及其进化潜力继续对人类种群中出现的新的(人畜共患)感染构成威胁，SARS冠状病毒的出现就是例证。2013年关于阳性链RNA病毒的会议现在回到Keystone研讨会的屋檐下，将涵盖基础和应用研究，并提供一个无与伦比的平台来讨论这一重要病毒组成员的独特和共同特征。资深和初级研究人员将齐聚一堂，讨论正链RNA病毒分子生物学、发病机制、进化和流行病学领域的最新发展，旨在将这些发现转化为诊断和控制这些病原体感染的新方法。

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Positive Strand RNA Viruses, organized by Eric J. Snijder and Ralf Bartenschlager. The meeting will be held in Boston, Massachusetts from April 28 - May 3, 2013. The general topic of this meeting is relevant to the NIAID mission with respect to the broad area of viral pathogen research. Originally initiated in 1986 as a Keystone Symposia meeting, and later continued by Dr. Margo Brinton as primary organizer for more than 25 years, the triennial international symposium on Positive Strand RNA Viruses has provided an international forum for recent research on human, animal, plant, insect, and bacterial viruses with positive-strand RNA genomes. These pathogens constitute the largest group of viral agents including a large number of important human pathogens like hepatitis C virus, West Nile and dengue viruses, hepatitis A virus and poliovirus. Furthermore, the enormous variety of positive-stranded RNA viruses found in animals, and their evolutionary potential, continues to pose a threat of novel (zoonotic) infections emerging in human populations as illustrated by the emergence of the SARS coronavirus. The 2013 meeting on Positive Strand RNA Viruses, now back under the roof of Keystone Symposia, will cover both basic and applied research and provide an unparalleled platform to discuss the unique and common features of the members of this important virus group. Experienced and junior researchers will come together to discuss the latest developments in the areas of the molecular biology, pathogenesis, evolution and epidemiology of positive-stranded RNA viruses, aiming to translate these findings into novel approaches to diagnose and control infections by these agents.