Frontiers in Aging and Regeneration Research (FrARR)

描述（由申请人提供）：这个R25研究教育应用程序题为：“前沿衰老和再生医学（FrARR）”，响应PAR-12-016，培训和导师有前途的初级和高级本科生从占主导地位的代表性不足的社区在复杂的老龄化研究，并鼓励和支持他们，因为他们开始研究生学习。FrARR提供：首先是充满活力的培训课程，然后通过高级导师的指导和同行指导，培育导师-学员伙伴关系，并通过年度研讨会和科学务虚会以及对职业轨迹的定量跟踪来充实。课程在HBCU机构提供，即泽维尔大学（1年和4年），莫尔豪斯（2年和5年）和梅哈里（3年），在杰拉尔德·沙滕（匹兹堡）和S.迈克尔·贾兹温斯基（杜兰），舒巴·凯尔（爱尔兰），温斯顿·汤普森（莫尔豪斯）和艾曼·阿尔·亨迪（梅哈里）。我们的科学顾问咨询委员会由老龄化、再生和健康差异领域的知名专家组成，负责监督这一举措。这五个具体目标是：产生的热情，激情和教师所接受的科学事业的承诺提供支持本科学员，因为他们完成MSTEM学位的智力和情感基础。这是通过概念教育和实验室培训来实现的，重点是与老龄化和非裔美国人社区有关的疾病和失调。教学训练包括：A.衰老生物学和干细胞模型; B。衰老和阿尔茨海默病的神经生物学;肌肉和骨骼老化; D.生殖衰老;和E.衰老的表观遗传学和环境调节剂，沿着补充实验室。二.培养坦诚的关于目前的障碍，招聘和保留我们最有才华的研究人员和培训，在负责任的研究行为，道德，法律的和社会影响，特别是少数民族的健康问题的研究差距。三.激励，使和维持学员，因为他们过渡到专业的职业生涯，与指导的研究项目和持续的职业建议。通过在伍兹霍尔举行的年度聚会研讨会上与MBL的老龄化课程同时进行演讲，增强他们日益增长的兴趣。课程校友提供同侪指导。四.鼓励和授权学员和校友通过指导他们通过研究生申请和入学过程，使他们能够快速，顺利地启动老化研究和再生医学博士研究。五、以量化的独立机制评估、改进和监控FrARR的优势和劣势，全面、纵向地跟踪学员的成绩，确保这些宝贵的资金能够量化地展示为明智的、具有成本效益的和富有成效的投资。总之，我们的总体目标是为代表性不足的学员提供研究策略和职业生涯启动方面的全面复杂培训，以推动衰老和再生医学前沿的科学工作者。

DESCRIPTION (provided by applicant): This R25 research education application entitled: 'Frontiers in Aging and Regenerative Medicine (FrARR),' responsive to PAR-12-016, trains and mentors promising junior and senior undergraduates from predominately underrepresented communities in sophisticated aging research, and encourages and supports them as they embark on graduate studies. FrARR offers: first, dynamic training courses, then nurtured Mentor-Trainee partnerships enhanced by guidance from Senior Mentors and peer-peer mentoring, enriched by annual symposia and scientific retreats, with quantitative tracking of career trajectories. The courses are offered at HBCU institutions, i.e. Xavier University (years 1 & 4), Morehouse (years 2 & 5) and Meharry (year 3), under the overall directorship of Gerald Schatten (Pittsburgh) and S. Michael Jazwinski (Tulane), with Shubha Kale Ireland (Xavier), Winston Thompson (Morehouse), and Ayman Al-Hendy (Meharry). Our Advisory Board of Scientific Counselors, composed of acclaimed experts in the fields of aging, regeneration and health disparities, oversee this initiative. The five specific aims are: I. Engendering the enthusiasm, passions and commitments to scientific careers embraced by the faculty provides intellectual and emotional underpinnings for supporting undergraduate trainees as they complete their MSTEM degrees. This is accomplished via conceptual education and laboratory training, focused on diseases and disorders relevant to aging and African- American communities. Didactic training includes: A. Biology of Aging and Stem Cell Models; B. Neurobiology of Aging and Alzheimer's disease; C. Muscle and Bone Aging; D. Reproductive Aging; and E. Epigenetics and Environmental Modulators of Aging, along with complementary labs. II. Fostering candid regarding current barriers to the recruitment and retention of our most talented researchers and training in responsible conduct of research, ethical, legal and societal implications, and especially problems of minority health disparities in research. III. Motivate, Enable and Sustain Trainees as they transition to professional careers, with mentored research projects and on-going career advice. Enhance their growing interests by their presentations at the Annual Reunion Symposia at Woods Hole contemporaneously with the MBL's Aging Course. Course alumni provide peer-peer mentorship. IV. Encouraging and empowering trainees and alumni by guiding them through the graduate application and matriculation processes so that they are rapidly and smoothly able to initiate doctoral studies in aging research and regenerative medicine. V. Evaluate, Improve and Monitor FrARR's strengths and avoid weaknesses with quantitative independent mechanisms, track trainees' achievements comprehensively and longitudinally, to ensure that these precious funds can be quantitatively demonstrated as wise, cost-effective and fruitful investments. In summary, our overall goals are to provide comprehensive sophisticated training in research strategies and career launching for underrepresented trainees to advance the scientific workforce pioneering the Frontiers in Aging and Regenerative Medicine.