Investigation of the molecular basis of human nevogenesis and melanoma initiation

痣的数量和一生暴露于太阳紫外线是黑色素瘤发展的主要风险因素。IRF 4基因与痣数量和黑色素瘤易感性之间的遗传关联已被报道。我们提出，该基因功能的变化将影响黑色素细胞/黑素瘤细胞的行为，它们对紫外线辐射的反应以及与周围细胞的相互作用。了解该基因的功能将为黑色素瘤的发生提供重要的见解。

The number of moles and lifetime exposure to solar UV are the major risk factors in melanoma development. A genetic association between the IRF4 gene and mole number and melanoma susceptibility has been reported. We propose that changes in the function of this gene will impact on the behaviour of melanocytes/melanoma cells, their response to UV radiation and interaction with surrounding cells. Understanding the function of this gene will provide crucial insight into the initiation of melanoma.