DNA Methylation

 描述(由申请人提供)：请求支持由Alexander Meissner和Dirk Schübeler组织的题为DNA甲基化的Keystone研讨会。会议将于2015年3月29日至4月3日在科罗拉多州的Keystone举行。DNA甲基化是哺乳动物发育所必需的，在包括植物在内的许多生物体中起着重要的调节作用。基因组学技术在DNA甲基化研究中的应用揭示了DNA甲基化是一种高度动态和信息量丰富的修饰，而不是经典的只参与稳定的长期沉默的观点。在建立和维持DNA甲基化以及绘制其全基因组位置图方面取得了重大进展。这些进展是由(I)技术的改进，(Ii)可以调节DNA去甲基化的酶的发现，以及(Iii)对其在癌症等疾病中的作用的日益认识推动的。然而，在完全了解方面仍然存在许多差距，特别是在具体疾病方面。关于DNA甲基化的Keystone研讨会会议(见所附程序)将重点介绍这些进展。同时召开的表观基因组学会议将大大增加将DNA甲基化与所提到的其他基因组调控层面相结合的机会，该会议将与本次会议分享主旨演讲和两次全体会议。

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled DNA Methylation, organized by Alexander Meissner and Dirk Schübeler. The meeting will be held in Keystone, Colorado from March 29-April 3, 2015. DNA methylation is essential for mammalian development and plays an important regulatory role in many organisms, including plants. The application of genomics techniques to the study of DNA methylation has revealed DNA methylation to be a highly dynamic and informative modification, rather than the classic view of being only involved in stable, long-term silencing. Major advances have been made in establishing and maintaining DNA methylation, as well as mapping its genome-wide location. These advances are being driven by (i) improvements in technology, (ii) the discovery of enzymes that can mediate DNA de-methylation, and (iii) the ever-increasing recognition of its role in diseases such as cancer. However, many gaps remain towards a complete understanding, particularly with respect to specific diseases. The Keystone Symposia meeting on DNA Methylation (see attached program) will highlight these advances. Opportunities for integrating DNA methylation with the other mentioned layers of genome regulation will be significantly enhanced by the concurrent meeting on Epigenomics, which will share the Keynote Address and two plenary sessions with this meeting.