Investigations into the architectural and biophysical features of optimal T cell receptor design
Investigations into the architectural and biophysical features of optimal T cell receptor design
批准号:
nhmrc : 496721
负责人:
A/Pr John Miles
金额:
$16.8万
依托单位国家:
澳大利亚
项目类别:
Early Career Fellowships
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2011-12-31
中文摘要
人类进化缓慢,病原体和癌症进化迅速。毫不奇怪,我们的免疫系统经常输掉这场军备竞赛,我们不可逆转地死于疾病。灾难性的是,每年有2600万人死于这些原因。该项目将使用一种新技术来快速推进人类免疫受体的进化,以构建一类超级受体。这些超级受体可能被证明是抗击癌症和传染病的决定性武器。
英文摘要
Humans evolve slowly, pathogens and cancer evolve quickly. Unsurprisingly, our immune systems often lose this arms race and we irreversibly succumb to disease. Catastrophically, >26 million people are lost every year to the these causes. This project will use a new technology to rapidly advance the evolution of human immune receptors to construct a class of super-receptor. These super-receptors may prove decisive weapons in the fight against cancer and infectious disease.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Using Methods in Genetic Epidemiology to Elucidate the Relationship Between Viral Infection and Risk of Autoimmune Disease
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批准号:nhmrc : 1125141
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项目类别:Project Grants
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资助金额:$42.47万
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财政年份:2017
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负责人:A/Pr John Miles
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依托单位:
Understanding and modulating the human immune system
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批准号:nhmrc : GNT1131732
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项目类别:Career Development Fellowships
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资助金额:$47.01万
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财政年份:2017
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负责人:A/Pr John Miles
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依托单位:
Using Methods in Genetic Epidemiology to Elucidate the Relationship Between Viral Infection and Risk of Autoimmune Disease
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批准号:nhmrc : GNT1125141
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项目类别:Project Grants
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资助金额:$62.24万
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财政年份:2017
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负责人:A/Pr John Miles
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依托单位:
Understanding and modulating the human immune system
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批准号:nhmrc : 1131732
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项目类别:Career Development Fellowships
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资助金额:$32.12万
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财政年份:2017
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负责人:A/Pr John Miles
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依托单位:
Defining the molecular and functional features of protective HIV-specific T cells
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批准号:nhmrc : 1106756
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项目类别:Project Grants
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资助金额:$40.59万
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财政年份:2016
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负责人:A/Pr John Miles
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依托单位:
Defining the molecular and functional features of protective HIV-specific T cells
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批准号:nhmrc : GNT1106756
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项目类别:Project Grants
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资助金额:$59.2万
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财政年份:2016
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负责人:A/Pr John Miles
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依托单位:
A new approach to the design and evaluation of T cell vaccines for cancer and infectious disease.
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批准号:nhmrc : 1078987
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项目类别:Project Grants
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资助金额:$26.28万
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财政年份:2015
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负责人:A/Pr John Miles
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依托单位:
Development of CD96 antibodies for cancer treatment
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批准号:nhmrc : 1093566
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项目类别:Development Grants
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资助金额:$54.73万
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财政年份:2015
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负责人:A/Pr John Miles
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依托单位:
Tracking the human immune system over years of life
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批准号:nhmrc : GNT1069281
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项目类别:Project Grants
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资助金额:$45.64万
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财政年份:2014
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负责人:A/Pr John Miles
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依托单位:
Determining the biological significance of allelic sequence variation within the T cell receptor loci
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批准号:nhmrc : 1067374
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项目类别:Project Grants
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资助金额:$41.85万
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财政年份:2014
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负责人:A/Pr John Miles
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依托单位:
Following the T cell repertoire over the human life course
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批准号:nhmrc : 1069281
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项目类别:Project Grants
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资助金额:$31.55万
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财政年份:2014
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负责人:A/Pr John Miles
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依托单位:
Tracking the impact of superinfection with a common Herpesvirus on T cell immunity in humans
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批准号:nhmrc : 1045870
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项目类别:Project Grants
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资助金额:$21.19万
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财政年份:2013
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负责人:A/Pr John Miles
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依托单位:
Investigations into supraphysiologic T cell receptors and T cell agonists.
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批准号:nhmrc : 1031652
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项目类别:Career Development Fellowships
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资助金额:$27.23万
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财政年份:2012
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负责人:A/Pr John Miles
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依托单位:
The role of long peptide epitopes in antiviral CD8+ T cell recognition.
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批准号:nhmrc : 1021620
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项目类别:Project Grants
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资助金额:$28.98万
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财政年份:2012
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负责人:A/Pr John Miles
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依托单位:
Investigations into the biology and functionality of the human T cell receptor
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批准号:nhmrc : 613664
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项目类别:NHMRC Project Grants
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资助金额:$28.29万
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财政年份:2010
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负责人:A/Pr John Miles
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依托单位:
Investigations into the cytolytic T cell response during Epstein-Barr virus related disease
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批准号:nhmrc : 389937
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项目类别:NHMRC Postgraduate Scholarships
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资助金额:$0.25万
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财政年份:2006
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负责人:A/Pr John Miles
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依托单位:
Cytotoxic T lymphocyte response to Epstein-Barr virus
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批准号:nhmrc : 339480
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项目类别:NHMRC Postgraduate Scholarships
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资助金额:$2.81万
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财政年份:2005
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负责人:A/Pr John Miles
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依托单位:
海外基金