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Investigations into the architectural and biophysical features of optimal T cell receptor design

Investigations into the architectural and biophysical features of optimal T cell receptor design
研究最佳 T 细胞受体设计的结构和生物物理特征
批准号:
nhmrc : 496721
负责人:
A/Pr John Miles
金额:
$16.8万
依托单位国家:
澳大利亚
项目类别:
Early Career Fellowships
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2011-12-31

项目摘要

项目成果

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相关文献

中文摘要
翻译
人类进化缓慢,病原体和癌症进化迅速。毫不奇怪,我们的免疫系统经常输掉这场军备竞赛,我们不可逆转地死于疾病。灾难性的是,每年有2600万人死于这些原因。该项目将使用一种新技术来快速推进人类免疫受体的进化,以构建一类超级受体。这些超级受体可能被证明是抗击癌症和传染病的决定性武器。
英文摘要
Humans evolve slowly, pathogens and cancer evolve quickly. Unsurprisingly, our immune systems often lose this arms race and we irreversibly succumb to disease. Catastrophically, >26 million people are lost every year to the these causes. This project will use a new technology to rapidly advance the evolution of human immune receptors to construct a class of super-receptor. These super-receptors may prove decisive weapons in the fight against cancer and infectious disease.
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Using Methods in Genetic Epidemiology to Elucidate the Relationship Between Viral Infection and Risk of Autoimmune Disease
  • 批准号:
    nhmrc : 1125141
  • 项目类别:
    Project Grants
  • 资助金额:
    $42.47万
  • 财政年份:
    2017
  • 负责人:
    A/Pr John Miles
  • 依托单位:
Understanding and modulating the human immune system
  • 批准号:
    nhmrc : GNT1131732
  • 项目类别:
    Career Development Fellowships
  • 资助金额:
    $47.01万
  • 财政年份:
    2017
  • 负责人:
    A/Pr John Miles
  • 依托单位:
Using Methods in Genetic Epidemiology to Elucidate the Relationship Between Viral Infection and Risk of Autoimmune Disease
  • 批准号:
    nhmrc : GNT1125141
  • 项目类别:
    Project Grants
  • 资助金额:
    $62.24万
  • 财政年份:
    2017
  • 负责人:
    A/Pr John Miles
  • 依托单位:
Understanding and modulating the human immune system
  • 批准号:
    nhmrc : 1131732
  • 项目类别:
    Career Development Fellowships
  • 资助金额:
    $32.12万
  • 财政年份:
    2017
  • 负责人:
    A/Pr John Miles
  • 依托单位:
海外基金