UAB Statistical Genetics Post-Doctoral Training Program

描述（由申请人提供）：分子生物学的持续发展、产生的大量数据以及所研究的表型的复杂性使得对复杂的、创造性的、最终经过严格验证的新方法的需求变得迫切，同时缺乏在统计遗传学/基因组学方面受过良好训练的个人。我们结构化但灵活的培训计划提供2-3年的奖学金，为统计遗传学/基因组学和心脏，肺和血液（HLB）相关研究的博士后科学家做好准备，并强调独立和创造性研究计划的发展。受训者必须有一个调查职业的未来目标。该计划旨在通过定期参加研究，课程和教学研讨会来培养独立严谨的调查技能。提供统计遗传学/基因组学基础和遗传/基因组分析中最先进的计算工具方面的培训。通过亚拉巴马大学伯明翰分校（UAB）的HLB相关调查项目提供应用经验。我们将通过新计划的心血管疾病，肺部和血液相关疾病的研讨会提供HLB培训。UAB在统计遗传学部分的发展上投入了大量资金，因此拥有异常强大的统计遗传学家集中，提供了独特的培训环境。该计划有几个显着的优势，包括：（1）统计遗传学/基因组学和遗传流行病学教师人数众多，并在跨主题的专业知识：（a）研究设计，（B）大型和复杂的谱系分析，（c）双胞胎和家庭数据建模，（d）数学/理论统计，（e）微阵列数据分析，（f）药物基因组学;（g）外显子组测序分析;（h）表观基因组数据分析;（i）下一代测序数据分析;（f）模式生物实验杂交分析;（2）与正在制作或拥有可应用统计遗传技术的现有数据集的应用HLB研究人员建立密切合作关系;（3）教师与大量的热情和经验，在培训中的先进水平;（4）在精神和物质上的大量支持正在为我们的大学创造一个充满活力的，积极的，并提供良好的研究环境这一努力提供。学员与统计遗传学教师合作，并由HLB研究合作教师共同指导。合作教师的多学科性质（医生，心理学家，统计学家，生理学家，遗传学家，流行病学家，心脏病学家，肺病专家等）允许多学科的经验。教师之间强大的合作关系促进了这种方法。

DESCRIPTION (provided by applicant): Continued advances in molecular biology, the vast data generated, and the complexity of the phenotypes being studied have made acute the need for sophisticated, creative, and ultimately rigorously validated novel methods and the simultaneous shortage of individuals well trained in statistical genetics/genomics. Our structured but flexible training program offers 2-3 year fellowships to prepare post-doctoral scientists for careers in statistical genetics/genomics and heart, lung and blood (HLB) related research and emphasizes growth of an independent and creative research program. Trainees must have a future goal of an investigative career. The program aims to develop independent rigorous investigative skills through regular participation in research, courses, and didactic seminars. Training is provided in foundations of statistical genetics/genomics and state-of-the-art computational tools in genetic/genomic analysis. Applied experience is provided via HLB-related investigative programs at the University of Alabama at Birmingham (UAB). We will provide HLB training through newly planned workshops in cardiovascular diseases, lungs and blood related diseases. UAB has invested heavily in development of a Section on Statistical Genetics and consequently has an unusually strong consolidated concentration of statistical geneticists offering a unique training environment. The proposed program has several notable strengths including: (1) A statistical genetics/genomic and genetic epidemiology faculty that is large in number and has expertise in topics spanning: (a) study design, (b) analysis of large and complex pedigrees, (c) modeling of twin and family data, (d) mathematical/theoretical statistics, (e) analysis of microarray data, (f) pharmacogenomics; (g) analysis of exome sequencing; (h) analysis of epigenomic data; (i) analysis of next generation sequencing data; and (f) analysis of experimental crosses in model organisms; (2) Close collaborative ties with applied HLB investigators who are producing or in possession of existing data sets to which statistical genetic techniques can be applied; (3) A faculty with substantial enthusiasm and experience in training at an advanced level; (4) Substantial support in both spirit and material are being provided for this effort by our University creating a dynamic, positive, and well-provisioned research environment. Trainees work with faculty in Statistical Genetics and are be jointly mentored by collaborating faculty in HLB research. The collaborating faculty's multidisciplinary nature (physicians, psychologists, statisticians, physiologists, geneticists, epidemiologists, cardiologists, pulmonary disease experts, etc.) allows multidisciplinary experience. Strong collaborative ties among the faculty facilitate this approach.