Endothelial Injury and Repair: CardioPulmonary Vascular Biology COBRE

描述（由申请人提供）：心肺血管生物学COBRE的总体目标是通过独特的跨学科方法将肺部和心血管疾病领域的一组研究人员聚集在一起，以提高对肺部和心脏疾病血管病理生物学的发病机制和治疗的理解。本提案的具体目的是：1 .联合多学科研究人员，在肺和心脏损伤的发病机制中研究血管损伤和修复。2. 提供研究支持，保护时间和指导，使初级研究人员能够在“孵化器”环境中获得独立的研究支持，再加上一个强大的计划，以培养职业发展和获得额外的研究技能。3. 确定并支持将获得资助的试点调查人员，以获取研究补助金的初步数据。4. 通过核心的指导和支持来支持初级和试点调查人员。为血管损伤和修复研究的多学科项目拨款建立基础。我们建议建立一个包括5名初级研究人员和1-2名试点研究人员的中心，由行政和细胞分离/器官功能中心提供支持。初级和试点调查人员将由注重职业发展的有成就的科学家指导。心血管血管生物学COBRE的一个独特之处在于，将医学博士、博士和医学博士/博士合作完成的血管生物学研究的共同主题融合在一起。外部咨询委员会的一组杰出的科学家将提供建议、监督和批评。该中心将由海洋国家研究所管理，这是一个位于普罗维登斯退伍军人医疗中心的非营利性研究和教育基金会。初级调查人员和导师是布朗大学Alpert医学院的教师，他们受雇于普罗维登斯VAMC，罗德岛医院或布朗大学。为该COBRE提供了慷慨和持续的机构支持。这个创新的多学科心肺血管生物学COBRE将提供一个环境，促进创造性和跨学科的方法来研究肺部和心血管疾病的血管成分的病理生物学。随着中心的发展，COBRE将扩大到包括血管壁的其他成分。通过将来自心血管和肺部背景的基础和临床科学家聚集到一个血管生物学中心，这个COBRE将加强对血管疾病发病机制和治疗的理解，并加强对这些疾病的研究，这些疾病在RI中很普遍。

DESCRIPTION (provided by applicant): The overall objective of the Cardiopulmonary Vascular Biology COBRE is to bring together a group of investigators in the fields of pulmonary and cardiovascular diseases in a unique trans-disciplinary approach to improve understanding of the pathogenesis and treatment of vascular pathobiology in lung and heart diseases. The Specific Aims of this proposal are: l. Unite a group of multidisciplinary investigators in studies f vascular injury and repair in the pathogenesis of lung and heart injury. 2. Provide research support, protected time, and mentoring to enable junior investigators to attain independent research support in an "incubator" environment, coupled with a robust program for the nurturing of career development and attainment of additional research skills. 3. Identify and support pilot investigators who will be funded to obtain preliminary data for research grants. 4. Support junior and pilot investigators through mentoring and support from the Cores. 5. Establish the basis for multidisciplinary program project grant(s) for research in vascular injury and repair. We propose a Center that includes 5 junior investigators and 1-2 pilot investigators, supported by Administrative and Cell Isolation/Organ Function Cores. Junior and pilot investigators will be mentored by accomplished scientists with a strong focus on career development. A unique feature of the Cardiopulmonary Vascular Biology COBRE is the melding under a common theme of vascular biology of research done by collaborating MDs, PhDs, and MD/PhDs. An outstanding group of scientists on the External Advisory Committee will provide advice, oversight, and critique. The Center will be administered by the Ocean State Research Institute, a non-profit research and education foundation located at the Providence VA Medical Center. The junior investigators and mentors are faculty at Alpert Medical School of Brown University, and they are employed by the Providence VAMC, Rhode Island Hospital, or Brown University. Generous and sustained institutional support has been provided for this COBRE. This innovative and multidisciplinary Cardiopulmonary Vascular Biology COBRE will provide an environment that fosters creative and trans-disciplinary approaches to study of pathobiology of vascular components of lung and cardiovascular diseases. As the Center develops, the COBRE will be broadened to include other components of the vascular wall. By bringing together both basic and clinical scientists from cardiovascular and pulmonary backgrounds into a vascular biology center, this COBRE will enhance understanding of pathogenesis and treatment of vascular diseases and enhance research of these diseases, prevalent in RI.