Mayo Center for Cell Signaling in Gastroenterology

概述（由申请人提供）：梅奥诊所胃肠病学细胞信号传导中心（C-SiG）的目标是将发现、转化和以患者为导向的研究人员联系起来，以加强对胃肠道细胞信号传导途径的理解和治疗利用，以改善消化系统疾病患者的健康。该研究基地由59名科学家组成，消化系统疾病相关资金为2300万美元（直接成本，增长70%）。C-SiG成员分为三个机制研究主题：1)离子通道/膜受体；ii)信号转导；3)遗传学和基因调控。我们的中心假设是，消化系统疾病患者临床护理的进步需要一个便利的基础设施，支持多学科科学家之间有意义的互动，研究细胞机制、途径和治疗靶点，以增强基础发现快速转化为临床试验。C-SiG的总体具体目标是：i)通过扩大已有的Gl科学家的技术和协作能力以及吸引其他学科的研究人员来促进多学科研究；li)制定和实施一个强有力的科学充实计划，包括研讨会、讲习班、专题讨论会、访问教师计划、小型实验室和基于网络的课程；iii)通过C-SiG核心提供专门的设备、技术、方法、试剂和专业知识，以协助C-SiG成员，包括：a)最先进的显微镜技术和咨询专业知识（光学显微镜核心）；b)加速和扩大生物标本采集、处理和注释（临床核心）；c)新兴遗传技术和模式系统（遗传学和模式系统核心）；iv)通过同行评审的试点和可行性计划确定和培养新的Gl研究人员；v)促进C-SiG成员与Mayo和其他Gl中心的其他Gl研究人员之间的协同互动，以促进因细胞治疗靶点识别而产生的临床试验；vi)与梅奥的其他NIDDK中心（如PKD中心）和现有的消化疾病研究核心中心共享技术，特别是在中西部（即中西部DDRCC联盟）。

DESCRIPTION, OVERALL (provided by applicant): The goal of the Mayo Clinic Center for Cell Signaling in Gastroenterology (C-SiG) is to connect discovery, translational, and patient-oriented investigators to enhance understanding and therapeutically exploit signaling pathways in gastrointestinal cells to improve the health of patients with digestive diseases. The Research Base consists of 59 scientists and $23 million (direct costs, 70% growth) in digestive disease related funding. C-SiG members are organized into three Mechanistic Research Themes: 1) Ion channels/membrane receptors; ii) Signal transduction; and, iii) Genetics and gene regulation. Our CENTRAL HYPOTHESIS is that advances in clinical care of patients with digestive diseases requires a facilitative infrastructure supporting meaningful interactions among multidisciplinary scientists investigating cellular mechanisms, pathways and therapeutic targets to enhance rapid translation of basic discoveries into clinical trials. C-SiG's OVERALL SPECIFIC AIMS are to: i) Foster multidisciplinary research by expanding technical and collaborative capabilities of established Gl scientists and attracting investigators from other disciplines; li) Develop and implement a robust Scientific Enrichment Program that includes seminars, workshops, symposia, a visiting faculty program, minisabbatical, and Web-based curricula; iii) Offer specialized equipment, technologies, methodologies, reagents, and expertise to assist C-SiG members through the C-SiG Cores, including: a) State-of-the-art microscopic technology and consultative expertise (Optical Microscopy Core); b) Accelerated and expanded biospecimen acquisition, processing, and annotation (Clinical Core); c) Emerging genetic technologies and model systems (Genetics and Model Systems Core); iv) Identify and nurture new Gl investigators via a peer-reviewed Pilot and Feasibility Program; v) Promote synergistic interactions between C-SiG members and other Gl investigators at Mayo and at other Gl centers to facilitate clinical trials resulting from the identification of cellular therapeutic tarets; vi) Share technologies with other NIDDK centers at Mayo (e.g., PKD Center) and existing Digestive Disease Research Core Centers, especially in the Midwest (i.e. Midwest DDRCC Alliance).