Cell Biology and Immunology of Persistent Infection

 描述（由申请人提供）：请求支持由赫伯特（Skip）W. Virgin，E.约翰·威利，安妮·奥加拉和安德里亚·林恩考克斯。会议将于2016年1月31日至2月4日在加拿大阿尔伯塔省班夫市举行。持续感染是世界各地发病率和死亡率的主要来源。然而，越来越清楚的是，细菌微生物组、病毒组和真菌组可以对宿主具有有益的作用。病原体的慢性感染代表了消毒免疫的失败，但负责持久性和宿主健康与感染引起的疾病之间的平衡的机制尚未完全了解。最近的发现表明，感染生物体和宿主对感染的反应两者的多个组分决定感染结果，这说明必须将一系列学科结合在一起来理解感染过程。 慢性感染的基本机制。本次研讨会旨在汇集不同的 研究人员在各自领域的前沿社区，以了解是否以及如何操纵持续性感染，以预防疾病和增强健康。

 DESCRIPTION (provided by the applicant): Support is requested for a Keystone Symposia meeting entitled Cell Biology and Immunology of Persistent Infection, organized by Herbert (Skip) W. Virgin, E. John Wherry, Anne O'Garra and Andrea Lynn Cox. The meeting will be held in Banff, Alberta, Canada from January 31-February 4, 2016. Persistent infections are a major source of morbidity and mortality around the world. However, it is increasingly clear that the bacterial microbiome, the virome, and the mycobiome can have beneficial roles for the host. Chronic infections with pathogens represent a failure of sterilizing immunity, but the mechanisms responsible for persistence and the balance between host health and disease resulting from infection are not completely understood. Recent discoveries reveal that multiple components of both the infecting organism and the host response to infection determine infection outcome, illustrating that a range of disciplines must be brought together to understand the fundamental mechanisms of chronic infection. This symposium is designed to bring together diverse communities of researchers at the cutting edge of their fields to understand whether and how to manipulate persistent infections to prevent disease and enhance health.