ATM Activation and its functional Importance in DNA damage response
ATM Activation and its functional Importance in DNA damage response
批准号:
nhmrc : 569591
负责人:
Dr Mark Graham
金额:
$37.04万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2011-12-31
中文摘要
ATM是人类遗传性疾病共济失调-毛细血管扩张症(A-T)中缺乏的蛋白质。这种综合征的特征是神经变性和癌症风险增加。ATM识别DNA中的损伤并促进其修复,以最大限度地降低遗传缺陷的风险。本项目旨在研究ATM的激活机制。这些信息对于理解ATM在预防癌症中的作用很重要。
英文摘要
ATM is the protein deficient in the human genetic disorder ataxia-telangiectasia (A-T). This syndrome is characterised by neurodegeneration and increased risk of cancer. ATM recognises damage in DNA and facilitates its repair to minimize the risk of genetic defects. The project is designed to investigate the mechanism of activation of ATM. This information is important to understand the role of ATM in preventing cancer.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Phosphatase regulators mediate long-term changes in presynaptic terminals
-
批准号:nhmrc : 1079160
-
项目类别:Project Grants
-
资助金额:$65.62万
-
财政年份:2015
-
负责人:Dr Mark Graham
-
依托单位:
To investigate the role of ATM protein in protecting against neurodegeneration
-
批准号:nhmrc : 1077989
-
项目类别:Project Grants
-
资助金额:$63.59万
-
财政年份:2015
-
负责人:Dr Mark Graham
-
依托单位:
Phosphatase regulators mediate long-term changes in presynaptic terminals
-
批准号:nhmrc : GNT1079160
-
项目类别:Project Grants
-
资助金额:$94.28万
-
财政年份:2015
-
负责人:Dr Mark Graham
-
依托单位:
To investigate the role of ATM protein in protecting against neurodegeneration
-
批准号:nhmrc : GNT1077989
-
项目类别:Project Grants
-
资助金额:$92.08万
-
财政年份:2015
-
负责人:Dr Mark Graham
-
依托单位:
Phosphorylation of synaptic vesicle glycoprotein 2 (SV2) regulates endocytosis of synaptotagmin for synaptic transmission
-
批准号:nhmrc : 1052494
-
项目类别:Project Grants
-
资助金额:$40.9万
-
财政年份:2013
-
负责人:Dr Mark Graham
-
依托单位:
Role of oxidative stress in activating ATM to protect against neurodegeneration
-
批准号:nhmrc : 1019996
-
项目类别:Project Grants
-
资助金额:$38.03万
-
财政年份:2012
-
负责人:Dr Mark Graham
-
依托单位:
Mechanisms of synaptic vesicle endocytosis revealed by its regulatory phosphoproteome
-
批准号:nhmrc : 571070
-
项目类别:NHMRC Project Grants
-
资助金额:$36.36万
-
财政年份:2009
-
负责人:Dr Mark Graham
-
依托单位:
Inhibitory signalling switches define the machinery of synaptic vesicle endocytosis
-
批准号:nhmrc : 531700
-
项目类别:Career Development Fellowships
-
资助金额:$25.84万
-
财政年份:2009
-
负责人:Dr Mark Graham
-
依托单位:
O-GlcNAc-phosphorylation: a novel post-translational modification regulating vesicle recycling.
-
批准号:DP0987706
-
项目类别:Discovery Projects
-
资助金额:$20.8万
-
财政年份:2009
-
负责人:Dr Mark Graham
-
依托单位:
国内基金
海外基金
基于CRISPR Activation转录激活系统的籼稻新型再生因子的挖掘
-
批准号:32301275
-
项目类别:青年科学基金项目
-
资助金额:30万元
-
批准年份:2023
-
负责人:陈璐
-
依托单位:
炎性反应中巨噬细胞激活诱导死亡(activation-induced cell death,AICD)的机理研究
-
批准号:30330260
-
项目类别:重点项目
-
资助金额:105.0万元
-
批准年份:2003
-
负责人:顾军
-
依托单位: