MEASUREMENT OF DIETARY BIOMAKERS IN EAGeR TRIAL

EAGeR试验是在美国四个医学中心进行的一项多中心、块随机、双盲、安慰剂对照试验。阿司匹林对妊娠和生殖的影响（EAGeR）试验是一项多中心、前瞻性双盲随机对照试验，旨在评估低剂量阿司匹林联合叶酸治疗对1228名有1-2次妊娠史的妇女妊娠和妊娠的影响。大型生物标本库可用于分析，并为测试多种假设提供了良好的平台。本提案旨在通过生物医学IDIQ机制申请资助，用于在EAGeR试验中测量储存的生物标本。提议的检测将提供丰富的生物标志物水平数据源，可以结合EAGeR试验中已经收集的大量数据来分析回答新的研究问题。

The EAGeR trial was a multi-center, block-randomized, double-blind, placebo-controlled trial conducted across four medical centers in the U.S. The Effects of Aspirin in Gestation and Reproduction (EAGeR) Trial is a multi-site, prospective double-blind randomized controlled trial designed to assess the effects of low-dose aspirin in combination with folic acid treatment on pregnancy and gestation among 1228 women with a history of 1-2 pregnancy losses. A large biospecimens repository is available for analysis and offers a good platform for testing multiple hypotheses. This proposal is to request funding through the Biomedical IDIQ mechanism for the measurement of stored biospecimens in the EAGeR Trial. The assays proposed will provide a rich data source on biomarker levels that can be analyzed to answer novel research questions in conjunction with the extensive data already collected in the EAGeR Trial.