Dartmouth Cystic Fibrosis Training Program

在这个应用中，我们提出了达特茅斯囊性纤维化培训计划（DCFTP）来培训下一个 新一代研究人员研究囊性纤维化（CF）的生物学和后遗症。寻求支持， 一个全面的，高度互动的，跨部门的培训计划，重点是CF 跨膜传导调节因子（CFTR）运输和宿主-病原体相互作用的背景下， 参见在请求支持的5年期间，我们预计将有12次资格后考试，博士预科 学生获得最多两年的培训支持。我们的项目汇集了 来自各个部门的专门研究人员（我们目前的项目包括 生物化学，化学，遗传学，医学，微生物学/免疫学，流行病学， 儿科和工程），以提供指导CF相关的研究博士和MD/博士生。在 本次提交，我们建议直接支持四名博士前研究员。最近改名的达特茅斯 囊性纤维化培训计划将在一个研究基地已经丰富的基础， 转化和临床CF相关研究。达特茅斯的CF研究项目已经从三个 1997年，美国国家卫生研究院向一个世界级科学家社区提供了一笔赠款， 6990万美元的研究经费总成本（直接加间接）。我们的计划有14个参与者 培训学院在一系列学科工作，CF研究为中心重点;所有培训学院 进行研究，资金充足，并教导和指导我们的学员。这群基础医生 科学家研究人员积极从事CF相关研究，具有细胞生物学，结构 生物学、微生物学、免疫学、遗传学、生物信息学、统计学、计算生物学和 蛋白质组学作为开发该计划的一部分，两门新课程和一个夏季生物信息学研讨会 培训学院开发了一个新的期刊俱乐部，一个联合互动小组， 会议已经成立，每年的务虚会已经扩大到包括学术和 来自美国东北部、美国和世界各地的制药/生物技术科学家。培训补助金和 DCFTP赞助的、针对受训者的强化活动提供了一个统一的基础，极大地促进了 这一群体具有惊人的互动性（过去5年中合作出版了24篇论文 在我们的培训和附属教师）和这些教师举行的合作赠款。这个程序 建立在达特茅斯研究CF的研究人员的历史优势之上。

In this application, we propose the Dartmouth Cystic Fibrosis Training Program (DCFTP) to train the next generation of researchers studying the biology and sequelae of cystic fibrosis (CF). Support is sought for a comprehensive, highly interactive, interdepartmental training program, with an emphasis on CF transmembrane conductance regulator (CFTR) trafficking and host-pathogen interactions in the context of CF. During the 5 year period of the requested support, we anticipate 12 post-qualifying exam, predoctoral students receiving a maximum of 2 years of training support. Our program has pooled the talents of dedicated investigators from a wide range of departments (our current program includes faculty in the departments of Biochemistry, Chemistry, Genetics, Medicine, Microbiology/Immunology, Epidemiology, Pediatrics, and Engineering) to provide instruction in CF-related research to PhD and MD/PhD students. In this submission, we propose to directly support four predoctoral fellows. The recently re-named Dartmouth Cystic Fibrosis Training Program will function in the context of a Research Base already rich in basic, translational, and clinical CF-related studies. The CF research program at Dartmouth has grown from three investigators and one NIH grant in 1997 to a community of world-class scientists that currently secures $69.9M in aggregate total (direct plus indirect) costs of research funding. Our program has 14 participating Training Faculty working in a range of disciplines, with CF research as the central focus; all Training Faculty conduct research, are well funded, and teach and mentor our Trainees. This group of basic- and physician- scientist researchers is actively engaged in CF-related research, with expertise in cell biology, structural biology, microbiology, immunology, genetics, bioinformatics, statistics, computational biology and proteomics. As part of developing this program, two new courses and a summer bioinformatics workshop have been developed by Training Faculty, a new Journal Club has been instituted, a joint interactive group meeting has been established, and the yearly retreat has been expanded to include academic and pharma/biotech scientists from across the Northeast, the US and the world. Training-grant funds and DCFTP-sponsored, Trainee-specific enhanced activities provide a unifying base that greatly facilitates the strikingly interactive nature of this group (evidenced by 24 collaborative publications in the last 5 years among our Training and Affiliated faculty) and the collaborative grants held by these faculty. This Program builds on the historical strengths of the investigators at Dartmouth studying CF.