Research Training in Hematology

我们的培训计划汇集了来自八个部门的二十二名教师，专注于两个 血液学和人类疾病的重要领域：血管生物学和干细胞 生物学/恶性血液病。主要目标是培养医学博士。和博士多学科的科学家 环境做持续的，独立的血液学研究。两个博士前职位要求 将由一批优秀的博士来填补还有医学博士博士学生在良好的建立研究生 在威斯康星州（UW）的大学课程。四个博士后职位被要求培养研究 跟踪参与临床（医学，儿科）和基础科学（生物医学工程， 生物分子化学、细胞和再生医学、医学微生物学和免疫学、肿瘤学和 病理学）部门。高度互动的培训教师分为三个兴趣小组：血管 生物学/炎症;免疫调节、造血发育/恶性肿瘤;干细胞生物学/骨 骨髓移植血管生物学方面的专业知识包括微流体学、蛋白质组学、细胞迁移， 细胞外基质生物学，炎症的细胞机制，嗜酸性粒细胞生物学，血管建模 以及细胞迁移、止血的分子方面和血栓形成状态。血液恶性肿瘤/干细胞 细胞生物学是由一个著名的干细胞研究小组领导的。专业知识包括胚胎（ES），诱导 多能干细胞（iPSC）和间充质干细胞生物学，正常和异常的表观遗传调节 造血分化;造血、白血病发生和淋巴细胞中的细胞内信号传导; 骨髓瘤免疫治疗、肿瘤免疫学、异基因骨髓移植临床前模型; 临床试验和骨髓成像，以及干细胞的临床应用。培训机会跨度 基础和临床研究;包括基因组学，蛋白质组学，代谢组学， 微流体、斑马鱼和鼠疾病模型以及干细胞移植。一个强有力的强调是， 转化研究和临床研究者的多学科培训。华盛顿大学临床和医学研究所（UW Institute for Clinical and 转化研究提供教学和学位课程的临床调查，职业发展， 指导专业知识。我们的学员在建立研究事业方面有着出色的记录。十五 博士前任命者现已完成博士学位度七个是学术人员或科学家 职位，三个是行业科学家，两个正在完成高级亚专业临床培训，一个是 师范学院的化学教授24名博士后研究生已完成 在过去的15年里，这些受训人员包括十一名助理教授，两名 副教授、三名学术科学家、两名工业科学家和两名完成培训的科学家。大 合格的候选人库，我们的培训师出色的指导记录，机构的承诺，以及广泛的 一系列的科学专业知识都有助于我们的学员在科学事业上取得成功。

Our training program brings together twenty-two faculty members from eight Departments to focus on two areas of broad importance for hematology and human disease: vascular biology and stem cell biology/hematologic malignancy. The primary goal is to train M.D. and Ph.D. scientists in a multi-disciplinary environment to do sustained, independent research in hematology. Two predoctoral positions are requested that will be filled from an outstanding pool of Ph.D. and M.D.-Ph.D. students in the well-established graduate programs at the University of Wisconsin (UW). Four postdoctoral positions are requested to train research track candidates from participating clinical (Medicine, Pediatrics) and basic science (Biomedical Engineering, Biomolecular Chemistry, Cell and Regenerative Medicine, Medical Microbiology & Immunology, Oncology, and Pathology) departments. The highly interactive training faculty cluster into three interest groups: vascular biology/inflammation; immune regulation, hematopoietic development/malignancy; and stem cell biology/bone marrow transplantation. Expertise in vascular biology includes microfluidics, proteomics, cellular migration, extracellular matrix biology, cellular mechanisms of inflammation, eosinophil biology, modeling of blood vessels and cell migration, molecular aspects of hemostasis and thrombophilic states. Hematologic malignancy/stem cell biology is led by a prominent group of stem cell investigators. Expertise includes embryonic (ES), induced pluripotent (iPSC) and mesenchymal stem cell biology, epigenetic regulation of normal and abnormal hematopoietic differentiation; intracellular signaling in hematopoiesis, leukemogenesis, and lymphocytes; immunotherapy of myeloma, tumor immunology, preclinical models of allogeneic bone marrow transplant; clinical trials and bone marrow imaging, and clinical applications of stem cells. Training opportunities span basic and clinical investigation; including cutting-edge technologies in genomics, proteomics, metabolomics, microfluidics, zebrafish and murine disease models, and stem cell transplantation. A strong emphasis is placed on translational research and multidisciplinary training of clinical investigators. The UW Institute for Clinical and Translational Research offers didactic and degree programs in clinical investigation, career development, and mentoring expertise. Our trainees have an excellent record of establishing research careers. Fifteen predoctoral appointees have now completed their Ph.D. degrees. Seven are in academic faculty or scientist positions, three are industry scientists, two are completing advanced subspecialty clinical training, one is a chemistry professor at a teaching college. Twenty-four post-doctoral trainees have completed their appointments on the grant in the past fifteen years. These trainees include eleven assistant professors, two associate professors, three academic scientists, two industry scientists, and two completing training. The large pool of qualified candidates, outstanding mentorship record of our trainers, institutional commitment, and broad range of scientific expertise all contribute to successful careers in science for our trainees.