NCANDA Research Project Site: SRI

项目总结/摘要 在年轻的成年期，饮酒量急剧增加，22岁时达到顶峰， 近一半的人报告酗酒。长期饮酒期间频繁酗酒 神经成熟跨越到20多岁中期可能会导致更大的大脑和认知效果比类似的 成年后的酒精使用作为对RFA-AA-17-003的回应，本申请提出了一项研究项目 国家酒精和青少年神经发育联盟第二阶段（NCANDA-2） 以确定青少年在青春期和青年期大量饮酒的预测因素和影响。 为了实现这一目标，NCANDA-2的SRI站点将继续跟踪169个旧金山弗朗西斯科湾区的队列 （所有5个研究中心的n=831）参与者（基线首次访视时年龄为12-21岁），以获取必要的数据， 促进我们对青少年发展的理解，以及青少年时期饮酒对青少年的影响。 成人大脑NCANDA-2将使用多模式神经成像，认知测试，行为评估， 生物标本采集和自然环境中的多模式评估。酒精检测 结果将集中在结构和功能成熟的大脑区域，积极发展期间 青春期和青年期，参与心理调节，对奖励做出反应， 易受酒精的神经毒性影响此外，SRI还将与匹兹堡大学合作， NCANDA网站研究青少年亚组中与睡眠相关的预测因素和饮酒的影响。 将在夜间访视时进行行为和电生理测量，包括 脑电图、睡眠期间听觉诱发慢波电位（K波）和心率 睡眠期间自主神经功能的变异性测量。睡眠与大脑结构的关系也将 研究了SRI还将与UCSD网站合作，在fMRI环境中收集Stroop任务， 评估增加饮酒与不增加饮酒的青少年在认知控制系统方面的变化。 发展中的性别差异，酒精使用模式和历史，酒精使用对大脑的影响，以及性别- 区分心理社会因素（例如，抑郁症状）将在分析中考虑。与 通过这次更新提供的额外纵向数据，我们将确定酒精暴露对 人类大脑的发展轨迹，并确定预先存在的心理生物学脆弱性， 可能改变青少年和年轻人酒精或其他物质使用障碍风险的药物， 其他心理健康和发展成果。

PROJECT SUMMARY / ABSTRACT During young adulthood, drinking dramatically increases, with binge-level drinking peaking at age 22 and nearly half of individuals reporting binge-level alcohol use. Frequent binge alcohol use during the protracted neuromaturation spanning into the mid-20s may result in greater brain and cognitive effects than similar alcohol use in later adulthood. In response to RFA-AA-17-003, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence second phase (NCANDA-2) to determine the predictors and effects of heavy adolescent alcohol use in adolescence and young adulthood. To achieve this, the SRI site of NCANDA-2 will continue to follow a cohort of 169 San Francisco Bay Area (n=831 across all 5 sites) participants (ages 12-21 at baseline first visit) to acquire the necessary data to advance our understanding of adolescent development and the effects of alcohol use during adolescence on the adult brain. NCANDA-2 will use multimodal neuroimaging, cognitive testing, behavioral assessment, biospecimen collection, and multimodal assessments in the natural environment. The examination of alcohol consequences will focus on structural and functional maturation of brain areas that actively develop during adolescence and young adulthood, are involved in psychological regulation, respond to rewards, and appear vulnerable to neurotoxic effects of alcohol. In addition, the SRI will collaborate with the University of Pittsburgh NCANDA site to study sleep-related predictors and effects of alcohol use in a subgroup of adolescents. Behavioral and electrophysiological measures will be made on overnight visits, including electroencephalography, auditory evoked slow-wave potentials during sleep (K-complexes), and heart rate variability measures of autonomic function during sleep. Sleep-brain structural relationships will also be investigated. SRI will also collaborate with the UCSD site to collect the Stroop task in the fMRI environment to evaluate changes in the cognitive control system for youth who increase drinking versus those who do not. Sex differences in development, alcohol use patterns and history, impact of alcohol use on the brain, and sex- differentiating psychosocial factors (e.g., depression symptoms) will be considered in analyses. With the additional longitudinal data provided by this renewal, we will determine the effects of alcohol exposure on the developmental trajectory of the human brain, and identify preexisting psychobiological vulnerabilities and resiliencies that may alter adolescents' and young adults' risk for alcohol or other substance use disorder and other mental health and developmental outcomes.