Vanderbilt Interdisciplinary Training Program in Alzheimer's Disease

拟议的T32项目将为博士前提供跨学科的翻译研究培训 阿尔茨海默病(AD)和相关神经退行性疾病的学生和博士后研究员。 利用范德比尔特大学丰富的机构资源和 培训教师，该计划将定位下一代基础、翻译和临床科学家 走向独立，为理解AD及其相关问题做出重大贡献 与神经退行性变、脑血管疾病相交。通过个性化的指导， 综合课程，并参与前沿研究，该计划将强调基础科学 以及阿尔茨海默病和痴呆的临床基础，重点是(A)细胞应激反应和 神经保护，(B)损伤的血液动力学和神经血管机制，(C)细胞调节和 膜蛋白功能，(D)记忆功能和功能障碍的机制，(E)发现和评价 治疗目标；(F)疾病的临床表现。学员将发展基本的研究技能 以及建立成功职业生涯的专业技能，以及对责任人的深切欣赏 进行研究。参与高质量的跨学科研究体验将综合 学员的知识基础、研究和专业技能，以及对研究道德的欣赏。每个人 学员的个性化培训计划将通过额外的机构或方案教学和 在这些早期的形成阶段，培养卓越的学术成就和科学创新的资源 职业发展。

The proposed T32 program will provide interdisciplinary, translational research training for pre-doctoral students and post-doctoral fellows in Alzheimer's disease (AD) and related neurodegenerative disorders. Leveraging the rich institutional resources of Vanderbilt University and interdisciplinary research strengths of the training faculty, the program will position the next generation of basic, translational, and clinical scientists to advance toward independence while making major contributions to the understanding of AD and its intersection with neurodegeneration and cerebrovascular disease. Through individualized mentorship, integrated curriculum, and involvement in cutting-edge research, the program will emphasize basic science and clinical fundamentals of AD and dementia focusing on (a) cellular stress responses and mechanisms of neuroprotection, (b) hemodynamic and neurovascular mechanisms of injury, (c) cellular regulation and membrane protein function, (d) mechanisms of memory function and dysfunction, (e) discovery and evaluation of therapeutic targets, and (f) clinical manifestations of disease. Trainees will develop essential research skills and professional skills for building a successful career along with a deep appreciation for the responsible conduct of research. Participation in a high quality interdisciplinary research experience will synthesize the trainee's knowledge base, research and professional skill set, and appreciation of research ethics. Each trainee's individualized training plan will be augmented by additional institutional or programmatic didactics and resources to foster academic excellence and scientific innovation during these early, formative periods of professional development.