Caribbean Primate Research Center Program

项目摘要/摘要： 该应用程序的主要目标是改进和维护加勒比灵长类动物研究中心(CPRC) 通过对运营、管理、兽医护理和研究的支持，提供独特的研究资源。这个 中巴合作伙伴关系由四个综合设施组成：(1)中非合作伙伴关系最有价值的卡约圣地亚哥野战站 拥有1938年从印度带到圣地亚哥(CS)的一群自由放养的恒河猴的研究资源。 (2)Sabana Seca野战站，CPRC总部位于圣胡安外10英里处， 来自Cayo Santiago殖民地的恒河猴在各种户外配置中用于生物医学和 在自由放养动物上不可行的行为研究；(3)病毒学和遗传学实验室 (LVG)，位于圣胡安的医学校区(MSC)，支持几项研究计划 以恒河猴为模型；(4)灵长类动物形态实验室，也设在 在MSC上，并保存了CPRC骨骼收藏，这些骨骼是 遗传学、发育、病理学和解剖学研究。如本提案所述，中国人民政治协商会议是由 分成四个互补和综合的部门：灵长类资源、病毒学和遗传学、行为和 神经科学和灵长类动物的形态。在本申请中申请资金用于维护CPRC基本 灵长类资源基础设施，用于支持许多地方、国家和 在国际上。这笔赠款还将允许中国红十字会继续支持翻译科学倡议(TSI)。 在应用研究部分下。TSI的一大优势是进行多学科的 为临床前翻译项目建立和验证NHP模型的协作研究 不同的人类疾病。在NIH的持续支持下，CPRC仍将是一项重要的全国性研究 资源，并将能够提供健康的印度起源的恒河猴明确的遗传和病毒学 美国国立卫生研究院赞助的研究项目的背景。

PROJECT SUMMARY/ABSTRACT: The major goal of this application is to improve and maintain the Caribbean Primate Research Center's (CPRC) unique research resources through support of operations, administration, veterinary care and research. The CPRC consists of four integrated facilities: (1) Cayo Santiago Field Station, the most valuable of the CPRC research resources that holds a colony of free-ranging rhesus brought from India to Cayo Santiago (CS) in 1938.; (2) the Sabana Seca Field Station, the CPRC's head quarters located 10 miles outside of San Juan that houses rhesus monkeys derived from Cayo Santiago colony in various outdoor configurations for biomedical and behavioral studies that are not feasible on free-ranging animals; (3) the Laboratory of Virology and Genetics (LVG), located on the Medical Sciences Campus (MSC), in San Juan which support several research initiatives using rhesus monkeys as a model; and (4) the Laboratory of Primate Morphology (LPM), which is also located on the MSC, and houses the CPRC skeletal collections, unique assemblages of nonhuman primate skeletons for genetic, developmental, pathological and anatomical research. As described in this proposal, CPRC is organized into four complementary and integrated divisions: Primate Resources, Virology and Genetics, Behavior and Neurosciences, and Primate Morphology. Funds are requested in this application to maintain CPRC basic infrastructure of Primate Resources, which are used to support numerous research projects locally, national and internationally. This grant will also allow CPRC to continue supporting the Translational Science Initiative (TSI) under the Applied Research Component. A major strength of this TSI is conducting multidisciplinary collaborative studies to establish and validate NHP models for preclinical translational projects related to different human diseases. With continued NIH support, the CPRC will remain a significant national research resource and will be able to provide healthy Indian-origin rhesus monkeys of defined genetic and virological background to NIH-sponsored research programs.