Minnesota Training Program in Virology

项目摘要/摘要 这是明尼苏达州病毒学培训计划的竞争性更新，此前 资助期。病毒学研究中的发现导致了对分子和 细胞的细胞过程、病毒复制和致病的基本机制以及如何宿主的策略 细胞对病毒感染作出反应(即病毒与宿主的相互作用)。病毒及其造成严重后果的能力 疾病和死亡对人类历史产生了深远的影响，并不断威胁着全球 健康和经济稳定。这项培训计划利用了32名经验丰富的培训师，他们正在指导 对各种重要病毒的研究。分子病毒学研究所(IMV)是焦点 明尼苏达大学(UMN)病毒学研究点，并作为 在资源不断减少的情况下，大学投资至关重要。这种投资包括8万美元- 占地6,300万美元的微生物研究设施于2015年开业，以及1400万美元用于额外的 生物医学发现区过去8年的研究基础设施。 我们计划培训活动的主要亮点包括实施基础课程 病毒学以及由IMV赞助的广泛活动，学员和讲师都参加了 提供重要的智力、技术和职业发展机会(例如，《病毒学周刊》 俱乐部，每月IMV研究进展研讨会，每季度IMV病毒研究创新讲座 一年一度的UMN-Mayo病毒学和基因治疗杰出讲座，IMV教育和 职业发展系列、一年一度的IMV研讨会、合作的“Wisc-e-Sota”T32研讨会，以及 研究中负责任的行为年度会议)。学员参加这些培训计划活动 促进了思想交流，促进了合作项目。对实习生进度的监督 在多个层面上进行监督，包括由培训计划执行委员会进行年度评估。 UMN吸引了优秀的博士前实习生。从这个池中，优秀的博士后实习生 根据每个教练员的研究计划的个人力量被招募到教练员实验室。实习生招聘是 通过IMV提供的广泛职业发展机会而得到加强，其中包括 主办国家和国际病毒学会议，使学生--包括代表人数不足的学生-- 少数民族学生-来到我们的校园，与我们病毒学的所有成员发展长期的互动 研究社区。尽管我们是一个相对年轻的培训项目，但我们在培训方面有着很好的记录 成就。为了用我们现有的资源完成我们的培训任务，我们请求支持6名博士后 在下一个5年筹资期间，每年的职位数。

Project Summary/Abstract This is a competitive renewal of the “Minnesota Training Program in Virology” following a highly productive funding period. Discoveries in virology research have led to many fundamental insights into molecular and cellular processes of cells, basic mechanisms of viral replication and pathogenesis, and strategies for how host cells respond to viral infection (i.e., virus-host interactions). Viruses and their capacity to cause serious diseases and death have had a profound impact on the history of humanity and continually threaten global health and economic stability. This training program utilizes 32 accomplished trainers, who are conducting research on a wide variety of important viruses. The Institute for Molecular Virology (IMV) serves as the focal point for virology research at University of Minnesota (UMN) and has championed virology research as a critically important university investment at a time of declining resources. Such investment includes a 80,000- square-foot, $63 million Microbiology Research Facility that opened in 2015 as well as $14 million for additional research infrastructure in the Biomedical Discovery District in the past 8 years. Key highlight's of the training activities of our program include implementation of foundational coursework in virology as well as a wide-range of IMV-sponsored activities attended by both trainees and preceptors that provide important intellectual, technical, and career development opportunities (i.e., weekly Virology Journal Club, monthly IMV Research in Progress seminars, quarterly IMV Innovations in Virus Research Lecture Series, annual UMN-Mayo Distinguished Lectures in Virology & Gene Therapy, the IMV Educational and Career Development Series, the annual IMV Symposium, a collaborative `Wisc-e-sota' T32 symposium, and annual sessions in Responsible Conduct in Research). Trainee participation in these training program activities have fostered the exchange of ideas and stimulated collaborative projects. Oversight of trainee progress is monitored on multiple levels, including yearly evaluations by the training program's executive committee. Outstanding predoctoral trainees are attracted to the UMN. From this pool, outstanding predoctoral trainees are recruited to trainer labs by the individual strength of each trainer's research program. Trainee recruitment is enhanced by the breadth of career development opportunities provided through the IMV that include the hosting of national and international virology meetings that brings students – including underrepresented minority students – to our campus to develop long-lasting interactions with all members of our virology research community. Despite being a relatively young training program, we have a strong record of training achievement. To fulfill our training mission with our available resources, we request support for 6 predoctoral positions per year for the next 5-year funding period.