Regenerative Engineering Training Program (RE-Training)

《再生工程培训计划》综述 我们的社会面临的一个主要健康挑战是过早死亡和与 供移植的健康供体组织或器官短缺，再生能力有限 我们的身体由于严重的伤害或疾病。需要融合不同学科的研究 创建新的框架、工具和新的通用语言，以便更好地支持解决方案 像前述那样的复杂问题。再生工程就是汇聚 先进材料科学，干细胞和发育生物学，物理科学，以及 用于重建或再生复杂组织和器官的转化医学。这样做的目的是 培训计划旨在提供培训下一代 精通再生工程开发和使用的融合研究人员 解决办法。具体地说，项目毕业生将有能力发展科学、技术和 临床知识和技能，使他们能够识别和解决与 组织和器官功能的恢复。该计划的核心创新要素包括：1)临床 沉浸式旋转以直接了解器官衰竭和组织重建的挑战 折磨病人和医生；2)一个3人的指导团队，包括1个临床、1个生命/身体 理科和1名工程系教员；3)在产品开发公司实习 涉及再生工程的专业知识；以及4)学习基本知识的体验式课程 实验技术。该项目设在高级再生工程中心 在西北大学，工程学院的不同教职员工将共同努力， 文科、理科和医学。西北大学有着悠久的跨学科发展历史 合作，并拥有资源和教学工具，建立一个独特的国家计划，以 培养新的领导者。受训者将接受分子和干细胞生物学教授的指导， 纳米技术、添加剂制造、再生工程、分子生物物理、生物材料、 生物电子学、外科手术和转化医学。持续合作的例子包括 再生膀胱、骨骼、血管、胰腺、肝脏、肾脏、皮肤、肌肉、 免疫系统和神经。我们计划在一年级和六年级培训3名博士前实习生 每年2-5年。学员将从生物医学系的申请者中挑选 工程学，包括那些来自医学科学家培训计划的人。我们预计将生产出 善于融合的下一代再生工程思想领袖 旨在应对上述社会健康挑战和改善患者状况的研究 结果。

Summary for the Regenerative Engineering Training Program A major health challenge that our society faces is premature death and morbidity associated with the shortage of healthy donor tissues or organs for transplantation and the limited regenerative capacity of our body due to serious injury or disease. Research that entails the convergence of disparate disciplines to create new frameworks, tools, and a new common language is positioned to better enable solutions to complex problems such as the aforementioned one. Regenerative engineering is the convergence of advanced materials science, stem cell and developmental biology, physical sciences, and translational medicine to reconstruct or regenerate complex tissues and organs. The objective of this training program is to offer the curriculum and environment needed to train the next generation of convergence researchers that are versed in the development and use of regenerative engineering solutions. Specifically, program graduates will have the capacity to develop scientific, technical, and clinical knowledge and skills that will enable them to recognize and solve challenges associated with the restoration of tissue and organ function. Core innovative elements of the program include: 1) clinical immersion rotations to gain direct insight into organ failure and tissue reconstruction challenges that afflict patients and physicians; 2) a 3-member mentorship team that includes 1 clinical, 1 life/physical sciences, and 1 engineering faculty member; 3) internships at companies with product development expertise involving regenerative engineering; and 4) experiential courses to learn essential experimental techniques. The program, housed in the Center for Advanced Regenerative Engineering at Northwestern University, will be a joint effort involving diverse faculty from the schools of engineering, arts and sciences, and medicine. Northwestern University has a long history of transdisciplinary collaborations and has the resources and pedagogical tools to establish a unique national program to train new leaders. Trainees will be mentored by preceptors working in molecular and stem cell biology, nanotechnology, additive manufacturing, regenerative engineering, molecular biophysics, biomaterials, bioelectronics, surgery, and translational medicine. Examples of ongoing collaborations include programs for the regeneration of bladder, bone, blood vessels, pancreas, liver, kidney, skin, muscle, the immune system, and nerves. We propose to train 3 pre-doctoral trainees in year 1 and 6 trainees for each of years 2-5. Trainees will be selected from applicants in the department of Biomedical Engineering, including those from the medical scientist training program. We expect to produce the next generation of regenerative engineering thought leaders that are competent in convergence research aimed at tackling the aforementioned societal health challenges and improving patient outcomes.