IDIQ BASE BIOMEDICAL ASSAY LABORATORY FOR THE DIVISION OF POPULATION HEALTH RESEARCH - PROJECT TRACKING AND CONSULTATION

人口健康研究部(DiPHR)就与人类生殖和发育、儿童和青少年健康和行为、孕妇护理等相关的各种主题进行研究。观察性和干预性研究都是由DiPHR的科学家设计和实施的，大多数研究包括收集各种不同的数据和生物标本。 所有的生物检疫都是使用批准的方案收集的，并在将其存入NICHD支持的储存库之前进行识别。承包商不应收到有关研究对象的身份信息或个人健康信息。采集的标本种类繁多，包括全血、脐带血、棕黄色大衣、血浆、血清、尿液、唾液、组织(如胎盘、大网膜脂肪)、毛发、指甲、卵泡液和精液、精液以及新生儿血斑。 DiPHR需要对这种多样化的标本类型进行多种因素的分析，包括生殖激素和其他激素的浓度；饮食生物标记物；细胞因子；代谢功能指标，包括脂肪酸、甘油三酯和葡萄糖的分析；免疫功能标记物；低水平的C-反应蛋白；以及用于整个外显子组测序和甲基化分析的DNA提取；用于表达阵列的RNA分离；以及微生物组分析。 DiPHR要求对收集的生物样本进行分析，包括血液(血浆、血清、白细胞等)、尿液、唾液、脂肪组织、卵泡液、精液和其他与特定研究计划相关的生物材料。建议的分析包括：类固醇激素浓度的测量；重金属的测量；抗氧化剂和其他营养标记物的测量，包括类胡萝卜素、生育酚、瘦素和瘦素受体；免疫系统标记物的测量；使用多重和ELISA技术测量不同分析物的灵活性；以及代谢组学、蛋白质组学和全基因组关联研究的量化。 DiPHR设计并进行从怀孕前到成年期的创新病因学和干预研究，重点关注成功生殖、孕妇及其婴儿的健康和福祉，以及儿童和青少年在整个生命周期中的最佳生长和发展。为实现这一目标，该司收集了与这些研究活动有关的未查明的人类生物标本。该司需要生物医学实验室提供服务，对生物标本进行经过验证的临床分析，并根据需要修改和(或)开发新的分析方法，以测量这些生物标本。

The Division of Population Health Research (DiPHR) conducts research on a variety of topics pertaining to human reproduction and development, child and adolescent health and behavior, and care of pregnant women, among other topics. Both observational and interventional research studies are designed and are implemented by DiPHR scientists, and most research includes collection of a diverse array of data and biospecimens. All biospecimens are collected using approved protocols and are de-identified prior to banking in NICHD-supported repositories. The contractor shall receive no identifying or personal health information about the study subjects. A wide range of specimen types are collected including whole blood, cord blood, buffy coats, plasma, serum, urine, saliva, tissues (e.g., placenta, omental fat), hair, nail clippings, follicular and seminal fluid, semen, and newborn blood spots. DiPHR requires analysis of this diverse collection of specimen types for a multitude of factors, including concentrations of reproductive and other hormones; dietary biomarkers; cytokines; indicators of metabolic function including analysis of fatty acids, triglycerides, and glucose; immune function markers; low levels of C-reactive protein; as well as extraction of DNA for whole exome sequencing and methylation analysis; RNA isolation for use in expression arrays; and microbiome analysis. DiPHR requires analysis of collected biological specimens including blood (plasma, serum, WBC, etc.), urine, saliva, adipose tissue, follicular fluid, seminal fluid, and other biologic material relevant for specific research initiatives. Proposed analyses include measurement of concentrations of steroid hormones; measurement of heavy metals; measurement of antioxidants and other nutritional markers including carotenoids, tocopherols, leptin, and leptin receptor; measurement of immune system markers; the flexibility to measure different analytes using multiplex and ELISA techniques; and quantification of metabolomics, proteomics, and genome-wide association studies. DiPHR designs and conducts innovative etiologic and interventional research from preconception through adulthood, focusing on successful reproduction, the health and well-being of pregnant women and their infants, and the optimal growth and development of children and adolescents across the lifespan. To accomplish this, the Division generates a collection of de-identified human biospecimens pertaining to these research activities. The Division requires the services of a biomedical laboratory to provide validated, clinical analyses of biospecimens as well as to modify and/or develop new analysis as needed to measure these biological specimens.