GENETIC AND TRAUMA-RELATED RISK FACTORS FOR PTSD

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的目标是首先开发一个基础设施，用于在格雷迪医院的普通非精神病人群中对与创伤相关的和情感性精神疾病进行大规模的遗传和心理研究，为亚特兰大市中心服务。主要目的是检查5HTTLPR和BDNF(Val66Met)等位基因作为创伤与创伤后应激障碍风险的中介因素，以及检查该人群中其他精神相关单倍型的频率。 在本报告所述期间，我们从600多名受试者中获取了样本，包括唾液DNA和与虐待、创伤、抑郁和创伤后应激障碍症状相关的详细表型信息。主要发现详细说明了儿童早期虐待对成人抑郁的影响和儿童早期虐待对创伤成人创伤后应激障碍的影响的基因x环境交互作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this project are to first develop an infrastructure for doing large scale genetic and psychological studies of trauma-related and affective psychiatric illness in the general non-psychiatric population at Grady Hospital, serving the inner-city in Atlanta. The primary aims are to examine the 5HTTLPR and BDNF (Val66Met) alleles as mediators of trauma in the risk for PTSD as well as to examine the frequencies of other psychiatrically related haplotypes in this population. During the reporting period we have obtained samples from over 600 subjects including salivary dna and detailed phenotype information related to abuse, trauma, depression, and ptsd symptoms. The principal findings detail gene x environment interactions mediating the effects of early childhood abuse on adult depression and of early childhood abuse on PTSD in traumatized adults.