IN VIVO CO-REGISTERED PROTON T1? AND SODIUM MRI OF THE HUMAN KNEE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 骨关节炎（OA）是由滑膜关节中关节软骨的生化分解引起的退行性疾病。蛋白聚糖（PG）的损失，软骨细胞外基质的组成部分，已被证明是早期OA的主要变化。T1 <$MRI已被证明是敏感的大分子之间的相互作用，如蛋白聚糖，和散装水。它可以作为早期生化变化的指标。由OA诱导的带负电荷的蛋白聚糖的损失导致的另一种早期生化变化涉及从组织中损失钠离子以平衡固定电荷密度。 钠MRI以前也被用于探索这种机制。以前的研究表明，这两种方法之间的相关性调查关节软骨的健康是相当强的。本研究旨在通过收集所有数据而不改变患者的位置来产生固有的共配准三维图像集。通过该方法获得的益处包括增加所收集的数据的局部化，因为获取相同的图像切片（具有相同的厚度和间距）。 所有人体研究均得到机构审查委员会的批准。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Osteoarthritis (OA) is a degenerative disorder resulting from the biochemical breakdown of articular cartilage in the synovial joints. A loss of proteoglycans (PG), a component of the extracellular matrix in cartilage, has been shown to be the predominant change in early OA. T1¿ MRI has been shown to be sensitive to the interactions between macromolecules, such as proteoglycans, and bulk water. It can then be used as an indicator of the early biochemical changes. Another early biochemical change resulting from the loss of negatively charged proteoglycans induced by OA involves the loss of sodium ions from the tissue to balance fixed charge density. Sodium MRI has also been used previously to explore this mechanism. Previous studies have shown the correlation between these two methods of inquiry into the health of articular cartilage to be quite strong. This study aims to produce innately co-registered three-dimensional image sets by collecting all data without altering the positioning of the patient. The benefits attained by this method include an increased localization of data collected because the same image slices (with identical thickness and spacing) are acquired. All human studies were approved by the Institutional Review Board.