OBESITY/INSULIN RESISTANCE, VITAMIN C AND ENDOTHELIN-1

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 随着身体肥胖的增加，动脉“血管舒张”（或尺寸增加）的能力降低，这可能导致与超重或肥胖相关的心血管疾病的风险增加。 可能导致这种血管舒张能力降低的潜在机制之一是血管收缩趋势增加（尺寸减小和/或血管舒张阻力降低），由称为内皮素-1的物质介导。 ET-1的产生和活性的升高与心血管疾病的风险增加有关。 本研究的另一个目的是比较维生素C补充剂（一种安全廉价的治疗方法）和定期有氧运动在降低动脉血管收缩倾向方面的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With an increase in body fatness the ability of arteries to "vasodilate"(or increase in size) is reduced which may contribute to an increased risk of cardiovascular diseases associated with being overweight or obese. One of the potential mechanisms that may contribute to this reduced vasodilator capacity is an increased tendency towards vasoconstriction (decrease in size and/or resistance to vasodilation), mediated by a substance called endothelin-1. Elevations in ET-1 production and activity has been linked to an increased risk of cardiovascular disease. An additional aim of this study is to compare the effects of vitamin C supplementation, a safe and inexpensive treatment, and regular aerobic exercise in reducing the tendency of arteries to vasoconstrict.