Molecular Epidemiology of Antibiotic Resistant Salmonella enterica Strains Causing Human Disease

沙门氏菌感染是由细菌引起的食物中毒报告的很大一部分，其中许多感染是由于抗生素耐药菌株。由抗生素耐药生物体引起的感染很难治疗，通常更严重，持续时间更长，导致住院时间更长。这些菌株主要来自食物，例如肉类，乳制品，家禽，鸡蛋和其他受污染的食品，但也可以来自其他来源。大部分食物污染的源头，都是来自食用动物身上的沙门氏菌。追查个别耐药性菌株的来源，对根除沙门氏菌十分重要。由于沙门氏菌种类繁多，其中一些只与特定的动物或禽鸟有关，因此必须准确识别。拟议的工作将使这一过程更加准确，通过使用分子技术明确地建立可疑的联系，并揭示使用当前数据和方法难以辨别的进一步联系。这将减少由于耐药菌株而导致的感染数量。

Salmonella infections are responsible for a substantial proportion of reported food poisoning cases caused by bacteria and many of these infections are due to antibiotic resistant strains. Infections caused by antibiotic resistant organisms are hard to treat and generally more severe, of longer duration, and result in longer hospital stays. These strains are mostly acquired from foods, e.g. meats, dairy products, poultry, eggs, and other contaminated food products but can also be derived from other sources. Salmonella strains harboured by food-producing animals are the source of most of the food contamination.Tracing the source of individual resistant strains is essential for eradication and as there are many Salmonella types, some of which are found associated only with specific animals or birds, accurate identification is needed. The proposed work will make this process more accurate by using molecular techniques to unequivocally establish suspected connections and reveal further ones that are difficult to discern using current data and methods. This should decrease the number of infections due to resistant strains.