OSTEOPENIA IN DISORDERED EATING AND ATHLETE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 该研究的目的是确定饮食失调的女性和男性骨质疏松症的患病率，以及确定影响饮食失调个体骨密度和骨丢失的一些主要因素。 饮食失调会导致骨骼变薄（骨密度降低）。 骨骼明显变薄被称为骨质减少或骨质疏松症，这取决于其严重程度。 有时变薄可能严重到足以导致骨折和骨折的骨头。 人们不知道是什么原因导致饮食失调的人骨头变薄。我们计划在这项研究中筛选500至1650名女性和200至325名男性。 本研究包括一次访视，将持续约3小时。 据我们所知，以前没有关于男孩或男性饮食失调的预测因素的研究。男孩和男人的运动员三联征包括饮食失调、性腺功能减退（睾酮缺乏）和骨质减少。 骨质减少的决定因素的研究一直局限于一些个别因素和不同的骨骼部位。 我们假设，有一个复杂的相互关系之间的食物摄入量，运动，激素和体重决定骨质疏松症在不同的骨骼网站，并进一步说，这些决定因素之间的不同骨骼网站。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the study is to determine the prevalence of osteoporosis in women and men with disordered eating, as well as identify some of the major factors that affect bone density and bone loss in individuals with disordered eating. Disordered eating can cause thinning of the bones (a decrease in bone density). Significant thinning of the bones is called osteopenia or osteoporosis, depending on its severity. Sometimes thinning can be severe enough to cause breaks and fractures of the bones. It is not known what causes the bones to thin in people with disordered eating. We plan to screen from 500 to 1650 women for this study and 200 to 325 men. This study consists of one visit, which will last approximately three hours. To our knowledge, there have been no previous studies of predictors of disordered eating in boys or men. The athlete triad in boys and men would consist of disordered eating, hypogonadism (testosterone deficiency), and osteopenia. Research of the determinants of osteopenia has been limited to a few individual factors and different skeletal sites. We hypothesize that there is a complex interrelationship between food intake, exercise, hormones, and weight which determines osteopenia at the different skeletal sites, and further that these determinants differ among the various skeletal sites.