CLINICAL TRIAL: THE EFFECTS OF TESTOSTERONE AND ACTONEL ON BONE DENSITY IN ANORE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 神经性厌食症是一种饮食失调，可导致骨骼变薄（骨密度降低）。 骨密度的显著降低被称为骨质减少或骨质疏松症。 有时骨密度的损失可能严重到足以导致骨折。 目前尚不清楚是什么原因导致神经性厌食症的骨骼变薄。 本研究的目的是评估两种不同的药物，生理性睾酮替代和利塞膦酸钠，对神经性厌食症患者骨密度的影响。 睾酮是一种由女性和男性的卵巢和肾上腺产生的激素，已被证明对预防骨质疏松症和维持男性肌肉质量很重要。 已显示替吉奥刺激称为成骨细胞的骨形成细胞，并增加绝经后妇女的骨形成和骨密度，但其对神经性厌食症妇女的骨形成或骨密度的影响尚不清楚。Actonel是一种用于绝经后妇女低骨密度的药物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Anorexia nervosa is an eating disorder that can cause thinning of the bones (a decrease in bone density). A significant decrease in bone density is called osteopenia or osteoporosis. Sometimes the loss of bone density can be severe enough to cause breaks and fractures of the bones. It is not known what causes the bones to thin in anorexia nervosa. The purpose of the study is to evaluate the effects of two different medications, physiologic testosterone replacement and risedronate, on bone density in subjects with anorexia nervosa. Testosterone is a hormone that is made by the ovaries and adrenal glands in both women and men and has been shown to be important for prevention of osteoporosis and maintenance of muscle mass in men. Testosterone has been shown to stimulate bone forming cells called osteoblasts, and to increase bone formation and bone density in post-menopausal women, but its effects on bone formation or bone density in women with anorexia nervosa are not known. Actonel is a medication that is prescribed for low bone density to postmenopausal women.