HIGH MASS-TO-CHARGE FOURIER TRANSFORM MASS SPECTROMETRY

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 研究的目的是了解离子运动的修改FTMS陷阱，构建陷阱的理论考虑的指导下，并测试的有效性的电补偿细胞研究MALDI产生的高质量离子。 该核心研究项目的目标是通过改变陷阱的电特性而不是通过增加磁场强度来改善对质荷比大于几千的生物分子离子的检测。 我们建议，仪器将不仅是中型蛋白质的兴趣，但也为肽在蛋白质组学应用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The purposes of the research are to understand ion motion in modified FTMS traps, to construct traps guided by the theoretical considerations, and to test the effectiveness of the electrically compensated cell to study high-mass ions generated by MALDI. The goal of this core research project is to improve the detection for biomolecule ions with mass-to-charge ratios greater than a few thousand by making changes to the electrical properties of the trap rather than by increasing the magnetic field strength. We suggest that the instrumentation will not only be of interest for mid-sized proteins but also for peptides in proteomics applications.