RESTORING NORMAL FREQUENCY AND DURATION OF FEMALE SEXUAL BEHAVIOR

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：提高对绒猴雌猴性反应调节的神经机制的认识，为临床干预女性性功能减退提供依据。 据估计，性功能障碍影响了43%的女性。目前还没有批准的药物治疗这种疾病。进一步的担忧是，雌激素和孕激素的激素治疗是不安全的，激发了对非甾体药物治疗的研究。5-羟色胺神经元系统参与调节一系列雌性哺乳动物的性行为，包括人类和非人类灵长类动物，但所涉及的机制还不清楚。我们已经开发了一个模型系统，与女性普通绒猴，以确定行为反应的药物活性化合物。本研究使用WNPRC Assay Services和Animal Services。出版物待定。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To improve our understanding of serotonin-related neural mechanisms regulating female sexual response in marmosets in order to develop more appropriate clinical intervention for sexual hypofunction in women. Sexual dysfunction affects an estimated 43% of women. Currently there are no approved drug therapies for this disorder. Further concerns that hormonal treatment with estrogens and progestogens are not safe motivates the search for non-steroidal pharmoacotherapy. The serotonin neuronal system has been implicated in regulating sexual behavior in a range of female mammals, including humans and nonhuman primates, but the mechanisms involved are not well understood. We have developed a model system with female common marmosets to determine the behavioral responses to serotonergically active compounds. This research used WNPRC Assay Services and Animal Services. Publications are pending.