JHU Center for Neuroscience Research

描述（由申请人提供）： 在我们的机构中心核心补助金的竞争性更新，以支持神经科学研究，我们建议保持和扩大三个现有的核心设施的运作在约翰霍普金斯大学医学院（JHU SOM），这是建立在该中心补助金的前一个资助期：多光子成像核心，单克隆抗体核心，和胚胎干细胞工程核心。这些设施目前提供必要的资源，并执行所需的服务，这是不切实际的个别实验室提供自己的。这些核心设施的使用将继续大大有利于NINDS资助的11个主要中心研究者的研究计划，以及JHU SOM的其他NINDS资助的研究者，通过提供独特的设备，新方法的培训和新试剂的开发。这三个核心提供的实验机会和技术服务是对JHU SOM NINDS资助的研究人员可用的其他核心设施的补充，但不会重复。11名主要中心研究者中有7名是神经科学部的成员，4名是神经内科的成员，1名是病理科的成员。主要中心研究者的研究计划解决了神经和神经胶质发育，突触结构和功能，感觉转导和基因表达的活性依赖性调节等领域尚未解决的问题。主要中心研究者的NINDS资助的研究项目的具体目标解决了关键的临床问题，包括神经系统疾病的发育起源，损伤或变性后神经元再生的促进，神经性疼痛的基础，以及神经退行性疾病（阿尔茨海默氏痴呆症和肌萎缩侧索硬化症）的起源。主要中心研究者组成了一个高度互动的小组，具有无缝协作研究工作的历史。该中心的目标是通过为这些研究人员和JHU SOM的其他NINDS资助的研究人员提供该机构其他地方无法提供的核心设施来增强现有的研究计划。

DESCRIPTION (provided by applicant): In this competitive renewal of our Institutional Center Core Grant to support neuroscience research, we propose to maintain and expand the operation of three existing Core facilities at the Johns Hopkins University School of Medicine (JHU SOM) that were established during the previous funding period of this Center Grant: a Multiphoton Imaging Core, a Monoclonal Antibody Core, and an Embryonic Stem Cell Engineering Core. These facilities currently provide necessary resources and perform required services that are impractical for individual laboratories to provide on their own. Use of these Core facilities will continue to greatly benefit NINDS-funded research programs of the eleven Primary Center Investigators, and also other NINDS-funded investigators at JHU SOM, by providing access to unique equipment, training in new methodologies, and development of new reagents. The experimental opportunities and technical services offered by these three Cores complement, but do not duplicate, other Core facilities available to NINDS-funded investigators at JHU SOM. Seven of the eleven Primary Center Investigators are members of the Department of Neuroscience, four are members of the Department of Neurology, and one is in the Department of Pathology. The research programs of the Primary Center Investigators address unresolved issues in the areas of neural and glial development, synaptic structure and function, sensory transduction, and activity-dependent regulation of gene expression. The Specific Aims of Primary Center Investigators' NINDS-funded research programs address critical clinical issues, including the developmental origins of neurological disorders, the promotion of neuronal regeneration following injury or degeneration, the underlying basis of neuropathic pain, and the origin of neurodegenerative disorders (Alzheimer's Dementia and Amyotrophic Lateral Sclerosis). The Primary Center Investigators constitute a highly interactive group with a history of seamless collaborative research efforts. The goal of this Center is to augment existing research programs by providing these investigators, and other NINDS-funded investigators at JHU SOM, with Core facilities that are not available elsewhere at this institution.