Translational Research Training Program in Environmental Health Sciences

这项申请是T32环境学院培训补助金的第二次竞争性延续 健康科学(EHS)：“EHS中的翻译研究培训计划”(T32-ES019851)，在 宾夕法尼亚大学(宾夕法尼亚)。这一培训赠款是唯一专门支持正式 宾夕法尼亚大学博士前和博士后水平的EHS研究培训，并满足基于学员的重大需求 对环境及其健康影响的兴趣和生物医学工作人员的需求。T32的使命 培训计划是为了培训下一代环境健康科学家，以识别 环境暴露导致疾病的机制，并将这些发现转化为 有效预防和治疗，改善公共卫生。研究性培训体现了 宾夕法尼亚大学P30环境健康科学核心中心翻译研究主题 卓越的环境毒理学(CEET)。这些主题包括：空气污染与肺部健康， 环境暴露与癌症、易感之窗和环境神经科学。这些 主题的基础是暴露评估、不良后果和对人类受试者的翻译， 社区和政策。培训通过环境证书计划的课程作业提供 健康科学，包括强制性的社区环境健康轮换，通过进行全面的- 时间转换研究项目在可能的情况下由基础科学家和临床科学家共同指导，以 在EHS中创造新的知识。48名杰出的培训补助金(TG)教职员工来自宾夕法尼亚大学和 费城儿童医院，22名临床科学家，21名女性。TG支持通用 经历包括一个研究俱乐部，一个专门的研讨会系列，一个致力于 翻译研究主题，以及美国环保局、寂静之春研究所、研究中心的可选外部项目 香料研究所和科学政策研究所，使受训者有机会从事其他职业 选择。T32奖项目前支持三名博士后研究员进行EHS学位论文研究 课题和四名博士后研究员进行有指导的EHS研究。博士前实习生将获得 总计三年(第二年完成EHS证书课程，两年完成学位论文研究) 对博士后实习生的资助期限为两到三年。实习生为一系列的职业生涯做好了准备 就业部门，例如学术界(EHS、药理学和毒理学)、政府机构(例如美国- EPA、CDC、FDA、NTP、NIEHS)；以及工业(药品、食品、化妆品和纳米技术)。在过去的两个周期中 培训补助金资助了29名学员，他们发表了108篇论文，校友们继续 在学术界和工业界从事科学工作。自上次竞赛更新以来，38%的学员是 在科学界的代表性不足，56%是女性。

This application is the second competing continuation of a T32 Institutional Training Grant in Environmental Health Sciences (EHS) entitled: “Translational Research Training Program in EHS” (T32-ES019851) at the University of Pennsylvania (Penn). This training grant is the only dedicated mechanism to support formalized EHS research training at the pre- and post-doctoral level at Penn and meets a significant need based on trainee interest in the environment and its health impact and biomedical work force need. The mission of the T32 Training Program is to train the next generation of environmental health scientists to identify the mechanisms by which environmental exposures cause disease and to translate these findings into effective prevention and treatment and improvements in public health. The research training reflects the translational research themes of Penn’s P30 Environmental Health Sciences Core Center, the Center of Excellence in Environmental Toxicology (CEET). These themes include: Air Pollution and Lung Health, Environmental Exposures and Cancer, Windows of Susceptibility and Environmental Neuroscience. These themes are underpinned by exposure assessment, adverse outcomes, and translation to human subjects, communities and policy. Training is provided through course work from the Certificate Program in Environmental Health Sciences which includes a mandatory Community Environmental Health Rotation, by conducting a full- time translational research project co-mentored where possible by a basic-scientist and clinician-scientist to generate new knowledge in EHS. The 48 distinguished Training Grant (TG) faculty come from Penn and Children’s Hospital of Philadelphia, 22 are clinician-scientists and 21 are women. The TG supports common experiences including a research club, a dedicated seminar series, an annual symposium dedicated to a translational research theme, and optional externships at US EPA, the Silent Spring Institute, the Research Institute for Fragrance Materials and a Science Policy Institute so that trainees are exposed to alternative career options. The T32 award currently supports three predoctoral fellows to conduct dissertation research on an EHS topic and four postdoctoral fellows to perform mentored EHS research. Predoctoral trainees are supported for a total of three years (2nd year completion of the Certificate Program in EHS and two years dissertation research) and postdoctoral trainees are supported for two to three years. Trainees are prepared for a suite of careers in the employment sector e.g. academia (in EHS, Pharmacology and Toxicology), government agencies (e.g. US- EPA, CDC, FDA, NTP, NIEHS); and industry (drug, food, cosmetic and nanotechnology). In the last two cycles the Training Grant has supported 29 trainees, who have published 108 papers and alumni have continued with scientific careers in academia and industry. Since the last competitive renewal 38% of the trainees were underrepresented in science and 56% were women.