Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules

摘要-父项目 内布拉斯加大学饮食分子预防肥胖疾病中心(NPOD) 支持识别预防、治疗和治愈肥胖症的生物信号和 相关疾病。NPOD的重点是食物传播的信号。由内布拉斯加州大学林肯分校领导 (UNL)与内布拉斯加州大学医学中心密切合作，NPOD调查人员 16个单位的终身教职之家，涉及基础和临床科学，包括营养、化学工程、 生物化学、胃肠病学和公共卫生，使NPOD成为一项真正的多学科努力。NPOD的 长期目标是加强内布拉斯加州的生物医学研究基础设施，同时抗击肥胖，这是一个主要的 影响美国公民的健康问题。NPOD生物医学研究卓越中心(COBRE)第一阶段 成功的成果包括超过9600万美元的外部资金奖励，以支持研究和375种学术出版物 中心的主题。十名初级调查人员通过两个队列得到了指导，其中五个队列中有四个 1个项目负责人从NPOD支助毕业，并确立自己为独立调查员 在中间。第五位项目负责人在毕业前前往欧洲的一个职位。第二批S五人组 项目负责人正处于他们的指导阶段。在第一阶段聘用了四名新教师，使 该中心为建立足够数量的研究人员奠定了必要的基础：NPOD的成员有 从该中心成立时的13名教职员工发展到目前的51名调查人员。在第1阶段，NPOD 在UNL园区翻新空间，创建一个研究核心，并在核心价值安装新设备 738,500美元，以满足中心成员不断变化的需求。管理核心提供对计划的监督 确保中心有效运作的活动。NPOD在第一阶段的众多成功将其定位为 通过旨在最大限度地提高中心成功的战略活动，利用Cobre第二阶段资金。具体来说， NPOD将通过增加五名初级调查人员来增加其临界研究人员数量 内布拉斯加州大学，利用飞行员和种子基金向该中心招聘新的初级和高级调查人员 提供资金，并继续发展战略联盟，与全州的补充计划 内布拉斯加州；2)为研究核心购置额外设备，并使实验设计正式化 通过行政核心提供的服务；3)加强中心的指导结构和 协作、多学科环境；以及4)实施招聘和招聘方法，以扩大 将基础营养和肥胖研究与临床、转化和社区研究相结合。通过 完成第二阶段，NPOD将按计划过渡到Cobre第三阶段，然后追求 NPOD的愿景是成为NIH指定的营养和肥胖研究中心。

SUMMARY – PARENT PROJECT The Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules (NPOD) at the University of Nebraska supports research on the identification of biological signals that prevent, treat, and cure obesity and related diseases. The emphasis of NPOD is on food-borne signals. Led by the University of Nebraska-Lincoln (UNL) in close collaboration with the University of Nebraska Medical Center, NPOD investigators have their tenure homes in 16 units crossing basic and clinical sciences, including nutrition, chemical engineering, biochemistry, gastroenterology, and public health, making NPOD a truly multidisciplinary endeavor. NPOD's long-term goal is to enhance the biomedical research infrastructure in Nebraska while combating obesity, a major health problem impacting U.S. citizens. NPOD's Centers of Biomedical Research Excellence (COBRE) Phase 1 successes include over $96M in external funding awards to support research and 375 scholarly publications on the center's theme. Ten junior investigators have been mentored through two cohorts, with four of the five Cohort 1 project leaders graduating from NPOD support and establishing themselves as independent investigators within the center. The fifth project leader departed for a position in Europe prior to graduation. Cohort 2's five project leaders are in the middle of their mentoring period. The hire of four new faculty during Phase 1 enabled the center to lay the groundwork necessary to establish a critical mass of researchers: NPOD's membership has grown from 13 faculty at the center's inception to its current count of 51 investigators. During Phase 1, NPOD renovated space on the UNL campus to create a research core and installed new equipment in the core worth $738,500 to meet the evolving needs of center members. An Administrative Core provides oversight of program activities to ensure the center functions effectively. NPOD's many successes in Phase 1 have positioned it to leverage Phase 2 COBRE funding via strategic activities designed to maximize center success. Specifically, NPOD will 1) increase its critical mass of researchers by hiring an additional five junior investigators at the University of Nebraska, recruiting new junior and senior investigators to the center using pilot and seed grant funding, and continuing to develop strategic alliances with complementary programs across the state of Nebraska; 2) acquire additional equipment for the research core and formalize experimental design services offered through the administrative core; 3) enhance the center's mentoring structure and collaborative, multidisciplinary environment; and 4) implement hiring and recruitment approaches to expand integration of fundamental nutrition and obesity research with clinical, translational, and community research. By the completion of Phase 2, NPOD will be on-track for transitioning into COBRE Phase 3 and then pursuit of NPOD's vision to become an NIH-designated Nutrition and Obesity Research Center.