North Colony Field Cage Shade Structure Bid Build

项目摘要 加州国家灵长类动物研究中心（CNPRC）支持了这一生产 自1990年以来，无特定病原体恒河猴用于艾滋病毒/艾滋病研究。初始 选择用于排除的药物包括猿猴逆转录病毒（SRV）、猿猴 免疫缺陷病毒（SIV）和猿猴T细胞嗜酸性病毒（STLV），基于 他们可能会干扰艾滋病研究。SPF计划还包括 疱疹B病毒，因为该病毒存在于猕猴组织中， 体液给猕猴工作人员。最初的殖民地发展是 根据检测和高频率检测以确定血清阳性或病毒的去除， 有可能传播病毒的阳性动物。这创造了一个 无特异性病原体（SPF 4）的印度恒河猴群用于AIDS research. CNPRC拥有24个半英亩的农田围栏，为恒河猴繁殖提供住房 殖民地目前有四个被分配到U42项目，以支持纯种的生产 SPF 4动物用于艾滋病研究。每一个这样的农田大棚可以容纳大约150个 动物，但通常由二十只雄性和五十只雌性的较小种群形成。一 典型的繁殖组由属于几个年龄组的动物组成， 严格的统治等级制度CNPRC保留了详细的行为和社会记录， 每个社会群体，以促进有关育种需要，研究， 支持和殖民地的福祉与几只成年雄性沿着建立母系 在群体形成和随后的几年中提供社会稳定。这些动物是一个长期的- 术语繁殖资源，并作为婴儿，青少年，成年人和老年人的国家资源 动物用于生物医学研究的研究人员来自美国各地。第18 CNPRC现有的野外网箱已经有了钢架空结构，以保护 动物在夏天的炎热和冬天的雨水。 其中大约有10个corpus是在20世纪70年代建造的，需要修理， 在过去的50年里，6例皮质骨存在结构问题和/或 不断恶化的遮阳罩，被放置在适当的地方，以保护户外动物从两个太阳 还有雨这些帆布遮阳结构被风和太阳损坏， 每隔几年更换一次。所要求的资金将用于购买一个钢铁开销 其中一个畜栏的避难所。该项目将购买更换19 '高，100'宽， 60英尺长的钢架天篷（类似于天井结构），将覆盖大约 相当于半英亩畜栏的四分之一，也就是6,000平方英尺。这些结构将 包括钢框架、金属屋顶和混凝土基脚。每个结构的寿命为50年 年根据畜栏的数量，每个畜栏可以生产25至35只幼崽。 年 该提案通过支持以下项目，与U42母赠款（U42OD010990）的目标保持一致： 为艾滋病研究提供健康的SPF印度恒河猴，并促进其 护理和安全有效地收集生物样本用于研究和SPF的能力 殖民地维护

PROJECT SUMMARY The California National Primate Research Center (CNPRC) has supported the production of Specific Pathogen Free rhesus macaques for HIV/AIDS research since 1990. The initial agents selected for exclusion included Simian Retrovirus (SRV), Simian Immmunodeficiency Virus (SIV) and Simian T Cell Lymphotrophic Virus (STLV), based on their potential to interfere with AIDS research studies. The SPF program also included Herpes B virus due to the risk posed by the presence of this virus in macaque tissue and body fluids to personnel working with rhesus macaques. Initial colony development was based on test and removal with a high frequency of testing to identity seropositive or virus- positive animals that had the potential to transmit the viruses in question. This created a colony of Specific Pathogen Free (SPF4) Indian origin rhesus macaques for AIDS research. The CNPRC has 24 half-acre field corrals that provide housing for the rhesus monkey breeding colony. Currently four are assigned to the U42 project to support the production of pedigreed SPF4 animals for AIDS research. Each of these field corrals can house approximately 150 animals but typically are formed with smaller populations of twenty males and fifty females. A typical breeding group consists of animals belonging to several age groups characterized by a strict dominance hierarchy. The CNPRC maintains detailed behavioral and social records of each social group to facilitate management decisions pertaining to breeding needs, research support and the colony’s wellbeing. Established matrilines along with several adult males provide social stability in the group formation and subsequent years. These animals are a long- term breeding resource and serve as a national resource for infants, juveniles, adults, and aged animals for use in biomedical research by investigators from throughout the United States. 18 of the existing field cages at the CNPRC already have steel overhead structures to protect the animals from the heat in the summer and the rain in the winter. Approximately 10 of these corrals were constructed in the 1970’s and have required repair and maintenance over the past 50 years. 6 of the corrals have either structural problems and/or deteriorating shade covers that were put in place to shelter the outdoor animals from both sun and rain. These canvas shade structures are damaged by wind and the sun and need replacement every few years. The requested funds will help purchase one steel overhead shelter for one of the corrals. This project will purchase a replacement 19' high, 100’ wide, and 60’ long steel-frame canopy covers (similar to patio structures) that will cover approximately one-quarter of a corresponding half-acre field corral, or 6,000 square feet. The structures will include steel framing, metal roofing, and concrete footings. Each structure has a life span of 50 years. Depending on the corral population each corral can produce between 25 to 35 infants per year. This proposal aligns with the aims of the parent U42 grant (U42OD010990) by supporting the provision of healthy, SPF Indian origin rhesus macaques for AIDS research and facilitating their care and the ability to collect biological samples safely and efficiently for research and SPF colony maintenance.