Contrast-Enhanced Whole-Heart Coronary MRA at 3.0T

描述（由申请人提供）：该项目的目的是开发用于在3.0特斯拉系统上无创检测冠状动脉疾病的磁共振成像技术。磁共振血管造影（MRA）是一种很有前途的筛选试验，以选择传统血管造影的候选人。在过去的十年中，冠状动脉MRA取得了实质性进展。然而，初步的临床研究表明，目前的冠状动脉MRA技术遭受大量的技术失败和假阳性。本项目的目标是开发新的冠状动脉MRA技术，以实现以下目标：（a）将空间分辨率提高6倍，图像在所有三个方向上都具有各向同性分辨率，一次扫描即可覆盖整个心脏;（B）大幅提高成像速度，以便在实际成像时间内获得整个心脏MRA;（c）改善运动补偿计划，以更一致和全面地消除由心脏和呼吸运动引起的图像伪影。3.0-特斯拉成像系统可以生成比传统的1.5特斯拉系统具有更高信号强度的图像。然而，在3.0特斯拉下对冠状动脉进行成像带来了严重的技术挑战，例如更高的射频功率沉积和更大的磁场不均匀性。将设计新技术来应对这些挑战。临床批准的造影剂将用于改善冠状动脉的可视化。开发的技术将在健康志愿者和冠状动脉疾病患者中进行验证。该项目的具体目标是：具体目标1：提高成像速度和运动补偿，以在约4分钟内实现具有0.7 mm各向同性分辨率的对比增强全心脏冠状动脉MRA具体目标2：优化对比增强全心脏冠状动脉MRA的SNR，并验证使用0.10 mmol/kg MultiHance输注可以实现足够的S.2 SNR具体目标3：评价3.0T对比增强全心MRA的诊断准确性，并验证3.0T对比增强全心MRA比1.5T SSFP MRA更准确地显示冠状动脉狭窄，并且相同的技术3.1允许延迟-该项目的终点是开发和初步临床验证一种新的3.0T成像方法能够以显著提高的空间分辨率和成像速度采集全心冠状动脉MRA，显著减少残留运动伪影。公共卫生相关性：冠状动脉疾病是美国的主要死亡原因。该项目的总体目标是开发新的磁共振成像技术，以提高冠状动脉疾病的诊断准确性，降低诊断成本，并改善患者护理。

DESCRIPTION (provided by applicant): The purpose of the project is to develop magnetic resonance imaging techniques for noninvasive detection of coronary artery disease on 3.0-Tesla systems. Magnetic resonance angiography (MRA) is a promising screening test to select candidates for conventional angiography. Substantial progress has been made in coronary MRA in the last decade. However, preliminary clinical studies reveal that current coronary MRA techniques suffer from substantial technical failures and false positives. The objectives of the proposed project are to develop novel coronary MRA techniques to achieve the following goals: (a) improving the spatial resolution by 6-fold from current protocols, images will have isotropic resolution in all three directions with whole-heart coverage in one scan; (b) dramatically increasing the imaging speed so that whole-heart MRA can be acquired in a practical imaging time; (c) improving motion compensation schemes to allow more consistent and complete elimination of image artifacts caused by cardiac and respiratory motion. 3.0-Tesla imaging systems can generate images with higher signal intensity than conventional 1.5-Tesla systems. However, imaging coronary arteries at 3.0-Tesla poses serious technical challenges such as higher radio-frequency power deposition and greater magnetic field inhomogeneities. Novel techniques will be designed to address these challenges. Clinically approved contrast media will be used to improve the visualization of coronary arteries. Developed techniques will be validated in healthy volunteers and patients with coronary artery disease. The specific aims of the project are: Specific Aim 1: To improve imaging speed and motion compensation to allow contrast-enhanced whole-heart coronary MRA with 0.7-mm isotropic resolution in approximately 4 min Specific Aim 2: To optimize SNR for contrast-enhanced whole-heart coronary MRA and verify that adequate S.2 SNR can be achieved with a 0.10-mmol/kg MultiHance infusion Specific Aim 3: To evaluate the diagnostic accuracy of 3.0T contrast-enhanced whole-heart MRA and verify that it can depict coronary artery stenoses more accurately than 1.5T SSFP MRA and the same technique 3.1 allows delayed-enhancement imaging of the coronary artery wall in the same session The end point of the project is the development and initial clinical validation of a new 3.0T imaging approach capable of acquiring whole-heart coronary MRA with dramatically improved spatial resolution and imaging speed, an markedly reduced residual motion artifacts. PUBLIC HEALTH RELEVANCE: coronary artery disease is the leading cause of death in the United States. The overall objective of the project is to develop new magnetic resonace imaging techniques to increase the diagnostic accuracy of coronary disease, to reduce costs of diagnosis, and to improve patient care.