UC Davis Alzheimer's Disease Core Center

项目摘要/摘要 非裔美国人(AA)和拉丁裔美国人是美国最大的两个少数群体，他们受到了不成比例的影响 由阿尔茨海默病和相关疾病(ADRD)以及其他一些共病的医学 疾病(如高血压、糖尿病等)。有来自基于人口的研究的证据表明，一般 少数群体的伤残率较高，因此目标1将审查在以下方面是否存在差距 再生障碍性疾病和拉丁裔与非西班牙裔的工具性日常生活活动(IADL)困难 白色的。了解、预防和改善潜在的健康差距是主要的公共卫生优先事项 因为较差的功能结果会转化为生活质量的差异和更大的经济负担。 目标2将检查与功能能力相关的关键因素是否存在差异 跨组。无论IADL的总体残疾水平是否存在差异，都可能存在 是不同的促成因素(例如，认知、身体功能和医学并存)。本研究 将解决在关于潜在差异和功能结果贡献者的知识方面的一个重要差距， 这对制定有效的公共卫生政策和调整干预措施具有重要影响。这 补充剂将使陈医生能够减轻她的临床责任，增加她的专注研究 时间，这将朝着她开发独立研究计划的长期职业目标努力 在消除种族歧视方面，少数族裔之间存在着差距。这份补充资料还将提供一项有指导的研究 在UCD阿尔茨海默病中心的经验，将进一步发展她在临床研究方面的经验 方法，并出版关于ADRD的同行评议的科学出版物，这将加强她现有的 少数民族认知老化的知识库。

PROJECT SUMMARY/ABSTRACT African Americans (AA) and Latinos, the two largest minority groups in the U.S., are disproportionality affected by Alzheimer's disease and related disorders (ADRD) as well as a number of other comorbid medical conditions (e.g. hypertension, diabetes, etc.). There is evidence from population-based studies that general rates of disability are higher among minorities, and thus Aim 1 will examine whether there are disparities in instrumental activities of daily living (IADL) difficulties among AA and Latinos compared to Non-Hispanic Whites. Understanding, preventing, and ameliorating potential health disparities is a major public health priority because poorer functional outcomes translate into disparities in quality of life and greater economic burden. Aim 2 will examine whether there are differences in key factors that are associated with functional abilities across groups. Regardless of whether there are disparities in overall level of IADL disability, there are likely to be different contributing factors (e.g., cognition, physical functioning, and medical co-morbidities). This study will address an important gap in knowledge about potential disparities and contributors to functional outcomes, which has important implications for developing effective public health policies and tailoring interventions. This supplement would allow Dr. Chan to reduce her clinical responsibilities and increase her dedicated research time, which would work towards her long-term career goal of developing an independent program of research in ADRD related disparities among ethnic minorities. This supplement would also provide a mentored research experience at the UCD Alzheimer's Disease Center that will further develop her experience in clinical research methodology and produce peer-reviewed scientific publications on ADRD, which would enhance her existing knowledge base of cognitive aging in minorities.