Administrative Core

项目概要-行政核心 行政核心（AC）负责项目的总体治理和领导，以确保 在预算和供资期内实现研究目标，并管理和减轻 成功的任何风险。该项目的科学基础是多学科的，需要一种结构化的方法 这也是足够灵活，允许新的科学发现和适应不断发展的研究 这些发现将促进RFA中规定的科学知识，并以整体为基础， 目标是通过高度创新和 精密方法AC旨在通过强有力的项目领导提供这种结构， 项目指导委员会，通过项目进行核心对核心的沟通、整合和协作 管理和团队管理计划以及与利益相关者的沟通和整合， 作为NINDS项目科学家，阿尔茨海默病中心（ADC）计划，Mark VCID联盟， 国家阿尔茨海默氏症协调中心（NACC）和神经成像实验室（LONI）。因此， AC将通过1）研究启动和2）研究实施强调项目管理， 直接支持科学研究领导层的需求，并识别障碍，及时做出响应 并优化资源分配，以达到既定的研究目标。因此，我们认为， 这一项目领导层非常适合实现这一核心的具体目标，即： 1)发展和维持一个透明和有效的治理和领导结构， 实施所提议研究的各个方面。 2)提供集成的基础设施和高效的物流，以无缝地推动整个项目 参与站点和项目核心的网络，包括合作资源站点，如NACC和 洛尼这包括制定一个适当的研究启动阶段和一个实施阶段， 沿着，并附有过渡到实施阶段的计划和时间轴， 成功 3)与主要利益相关者建立及时的沟通、协调和协作， 传播和应用项目产生的新知识。 影响：AC领导层在多地点研究方面拥有丰富的经验，并充分了解 定义现场绩效以及计划如何监控、衡量绩效所需的标准 并满足期望。

PROJECT SUMMARY – Administrative Core The Administrative Core (AC) is responsible for the overall governance and leadership of the project to assure that the goals of the study are achieved within the budget and funding period as well as manage and mitigate any risks to success. The science underlying this project is multidisciplinary, requiring a structured approach that is also sufficiently flexible to allow for new scientific discovery and accommodate evolving research findings that will advance scientific knowledge as specified in the RFA as well as being grounded in the overall goal of impacting future clinical practice and possible future clinical trials design through a highly innovate and precision methods approach. The AC is designed to provide this structure through strong project leadership via the Project Steering Committee, core-to-core communication, integration and collaboration through the Project Management and Team Management plans as well as communication and integration with stakeholders such as NINDS Project Scientists, the Alzheimer's Disease Centers (ADC) Program, the Mark VCID consortium, the National Alzheimer's Coordinating Center (NACC) and the laboratory of Neuroimaging (LONI). As such, the AC will emphasize project management through both 1) study start-up and 2) study implementation that directly supports the needs of the scientific study leadership as well as identify barriers, make timely responses and optimize the allocation of resources to meet the defined study objectives. As a consequence, we believe that this project leadership is well suited to implement the specific aims of this core that are to: 1) Develop and maintain a transparent and effective governance and leadership structure to design and implement all aspects of the proposed research. 2) Provide an integrated infrastructure and efficient logistics to seamlessly drive the project across the network of participating sites and project cores, including collaborating resource sites such as NACC and LONI. This includes developing an appropriate study start-up phase and an implementation phase for the project, along with a plan and timeline for transitioning to the implementation phase with high likelihood of success. 3) Establish timely communications, coordination, and collaboration with major stakeholders to facilitate dissemination and application of new knowledge deriving from the project. Impact: The AC leadership has considerable experience with multisite studies and fully understands the criteria necessary to define site performance, as well as to plan how performance will be monitored, measured and addressed to meet expectations.