Graduate Training at the Chemistry Biology Interface

描述（由申请人提供）：本提案是马里兰大学巴尔的摩分校（UMBC）化学-生物界面研究生课程的续期申请。该项目于1998年在UMBC开始，直到2004年7月首次颁发为止，一直由大学单独资助。该项目旨在为化学、生物化学和生物学专业的学生提供跨学科的培训机会。迄今为止，已有13名博士生获得了培训补助金，另有19名博士生获得了大学增加的津贴。UMBC CBI项目的学生是四个博士学位项目的一部分；化学，生物学，分子和细胞生物学以及由马里兰大学化学系和马里兰大学巴尔的摩分校（UMB）市中心校区生物化学和分子生物系联合开展的生物化学项目。交叉学科的训练可以通过多种方式完成，一是在相反学科的实验室进行轮转的可能性，一是在相反学科的高级课程，两周一次的会议形式的课堂CHEM 715，“化学-生物学界面的问题”，在那里学生参与关于职业问题的讨论，学习如何进行研究演讲，回顾和展示各种“热门”话题领域的文献；以及接待来访的研讨会演讲者。更重要的是，自初始资助期以来，该计划增加了一个新功能，即由学生的研究导师与培训机会导师共同为每个学生专门设计的与相反学科导师一起进行正式培训的机会。新的培训机会的目的是给学生一个更有意义的经验，除了加强他们的论文研究。目前学生的研究项目包括：“激活乳腺癌特异性CD4+ T细胞的新型MHC限制性肽”，“Rob和SoxS的蛋白-蛋白相互作用及其在大肠杆菌应激防御反应系统中的作用”，“新型G蛋白偶联受体黑素磷酸化依赖性失活的研究”，“S100B结合抑制p53结合的小分子特征”，“APE1在刺激DNA糖基化酶中的重要性”，“TDG与APE1关系的表征”和“氨基黄酮抗癌药物活性代谢物的化学表征”。我们项目的独特之处在于，CBI学生从一年级开始参与，直到毕业，无论他们是否获得培训资助，从而确保持续的指导，指导和接触跨学科科学。

DESCRIPTION (provided by applicant): This proposal is a renewal application for the Chemistry-Biology Interface Graduate program at the University of Maryland, Baltimore CO (UMBC). This program was started at UMBC in 1998, and solely funded by the university until the initial award in July 2004. The program was initiated to provide opportunities for cross-disciplinary training for chemistry, biochemistry and biology students. To date thirteen Ph.D. students have been funded by the training grant in addition to another nineteen Ph.D. students that have received increased stipends from the university. Students in the UMBC CBI program are part of four Ph.D. degree programs; Chemistry, Biology, Molecular and Cellular Biology and the joint Biochemistry program run by the Chemistry department at UMBC and the Department of Biochemistry and Molecular Biology at the University of Maryland Baltimore (UMB) downtown campus. Cross-disciplinary training is accomplished in a number of ways, one, the possibility for a rotation in a laboratory in the opposite discipline, an upper level course in the opposite discipline, biweekly meetings in the form of a class CHEM 715, "Issues at the Chemistry-Biology Interface", where the students participate in discussions on career issues, learn how to give research talks, review and present literature from a wide variety of "hot" topic areas, as well as to host visiting seminar speakers. More significantly, a new feature of the program has been added since the initial funding period, a formal training opportunity with a mentor in the opposite discipline, specifically designed for each student by the student's research mentor in conjunction with the training opportunity mentor. The new training opportunity is designed to give the student a more meaningful experience in addition to enhancing their dissertation research. Some of the current students' research projects include: "Novel MHC ll-restricted peptides for activating breast cancer-specific CD4+ T cells", "Protein-Protein Interactions of Rob and SoxS and their Role in Stress Defense Response Systems in E. coli", "Investigation of phosphorylation dependent deactivation of the novel G protein coupled receptor melanopsin", "Characterizing S100B Bound to Small Molecules that Inhibit p53 Binding", "The Importance of APE1 in the Stimulation of DNA Glycosylases", "Characterization of the Relationship between TDG and APE1", and "Chemically characterizing the active metabolite of aminoflavone anticancer drugs". Unique to our program, the CBI students participate from year one until they graduate, regardless of whether or not they are on the training grant, thus insuring continual mentorship, guidance and exposure to cross-disciplinary science.