Pathogenesis of Influenza: Virus-Host Interactions

描述（由申请人提供）：本提案要求支持由Siamon Gordon， Malik Peiris和Kanta Subbarao组织的题为“流感发病机制：病毒-宿主相互作用”的Keystone专题会议，该会议将于2011年5月23日至28日在中国香港举行。流感发病机制仍有争议。病毒复制的直接细胞病变效应、病毒的组织趋向性、病毒-细菌协同作用以及先天宿主反应是密不可分的，并在“季节性”、人畜共患流感和大流行性流感（例如1918年和2009年的大流行以及H5N1禽流感）中发挥不同程度的作用。动物模型虽然必不可少，但在与人类疾病的生理相关性方面存在重大局限性。本次会议汇集了研究病毒、病毒受体和组织趋向性、先天和适应性免疫、系统生物学以及肺损伤和宿主防御的临床方面的研究人员，以解决有关流感发病机制的问题。其目的将是整合来自动物和人类实验模型（包括离体和体外）以及人类疾病的数据，以了解流感的发病机制以及这可能如何导致有效的干预措施。由于本次专题讨论会是在40年来第一次大流行之后举行的，因此将会有丰富的新知识以及对这一主题的强烈科学兴趣。鉴于亚太地区因H5N1禽流感和严重急性呼吸系统综合症的经历而对流感和其他病毒性呼吸道疾病产生了特别的兴趣，将会议设在香港将是特别合适的。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Pathogenesis of Influenza: Virus- Host Interactions, organized by Siamon Gordon, Malik Peiris and Kanta Subbarao, which will be held in Hong Kong, China from May 23 - 28, 2011. The mechanisms underlying the pathogenesis of influenza remain controversial. The direct cytopathic effects of viral replication, tissue tropism of the virus, viral-bacterial synergy, as well as innate host responses are inextricably linked and play roles to varying degrees in "seasonal," zoonotic and pandemic influenza, examples being the pandemics of 1918 and 2009 and H5N1 avian influenza. Animal models, though indispensible, have significant limitations with regard to physiological relevance to human disease. This meeting brings together researchers working on the virus, viral receptors and tissue tropism, innate and adaptive immunity, systems biology and clinical aspects of lung injury and host defense to address questions on the pathogenesis of influenza. The aim will be to integrate data from animal and human experimental models - both ex vivo and in vitro - as well as human disease to understand pathogenesis of influenza and how this may lead to effective interventions. As this symposium will take place in the aftermath of the first pandemic in 40 years, there will be a wealth of new knowledge as well as intense scientific interest in the subject. In view of the particular interest in influenza and other viral respiratory diseases generated in the Asia-Pacific region arising from the avian flu H5N1 and SARS experience, situating the meeting in Hong Kong will be particularly appropriate. PUBLIC HEALTH RELEVANCE: Pandemic influenza remains a major public health issue. There is an urgent need to better understand the origination and development - or pathogenesis - of severe viral infections that cause lung injury, and to explore novel therapeutic options targeting the host. The Keystone Symposia meeting on Pathogenesis of Influenza: Virus-Host Interactions aims to improve our understanding of determinants that facilitate inter- species transmission of influenza viruses.