Environmental Epigenomics and Disease Susceptibility

描述（由申请人提供）：该提案请求支持由兰迪·L·卡勒（Randy L. Jirtle，Moshe Szyf和Frederick L.泰森，这将是在阿什维尔，北卡罗来纳州从2011年3月27日至4月1日。现在有令人信服的人类流行病学和动物实验数据表明，成人发病的复杂疾病和神经系统疾病的风险受到产前和产后早期环境暴露的持续表观遗传适应的影响。因此，为了有效地促进公共健康，关键是要确定环境因素，如内分泌干扰物，营养补充剂和养育行为是否可以通过修改表观基因组而不是突变基因组来改变成人疾病的发病机制。这些是将在Keystone环境表观基因组学和疾病易感性研讨会会议上深入讨论的科学主题。更具体地说，本次会议的目的是提供证据，证明在早期发育期间的环境暴露，通过修改表观基因组，可以改变发展医疗条件的风险，如哮喘，自闭症，癌症，心血管疾病，糖尿病，肥胖症和精神分裂症在以后的生活中。特别是，环境引起的表观遗传效应对大脑发育的重要性将在这次会议上强调。 公共卫生相关性：健康和疾病状态下的复杂生物学过程涉及许多基因和外部影响（如环境化学品，压力源，营养和药物）之间的基因-环境相互作用（或表观遗传学）。事实上，环境因素与许多疾病有关，包括自闭症、双相情感障碍、癌症、心血管疾病、糖尿病、肥胖症和精神分裂症。关于环境表观基因组学和疾病易感性的Keystone研讨会将研究早期发育期间环境暴露的证据，通过修改表观基因组，可以改变以后生活中发展医疗条件的风险。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Environmental Epigenomics and Disease Susceptibility, organized by Randy L. Jirtle, Moshe Szyf and Frederick L. Tyson, which will be held in Asheville, North Carolina from March 27 - April 1, 2011. There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders is influenced by persistent epigenetic adaptations in response to prenatal and early postnatal environmental exposures. Thus, to effectively promote public health, it is critical to determine whether environmental factors as diverse as endocrine disruptors, nutritional supplements, and nurturing behavior can alter the pathogenesis of adult diseases by modifying the epigenome rather than mutating the genome. These are the scientific topics that will be discussed in depth at the Keystone Symposia meeting on Environmental Epigenomics and Disease Susceptibility. More specifically, the objective of this meeting is to provide evidence that environmental exposures during early development, by modifying the epigenome, can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life. In particular, the importance of environmentally-induced epigenetic effects on brain development will be stressed in this meeting. PUBLIC HEALTH RELEVANCE: The complex biological processes underlying states of health and disease involve gene-environment interactions (or epigenetics) between many genes and external influences such as environmental chemicals, stressors, nutrition, and drugs. In fact, environmental agents have been associated with a number of diseases including autism, bipolar disorder, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia. The Keystone Symposia meeting on Environmental Epigenomics and Disease Susceptibility will examine the evidence that environmental exposures during early development, by modifying the epigenome, can alter the risk of developing medical conditions later in life.